Entrez gene ID | | 246778 |
Official gene symbol | | IL27 |
Full name | | interleukin 27 |
Aliases | | ,IL-27,IL-27A,IL27p28,IL30,MGC71873,p28, |
Gene summary | | The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq] |
Location | | Chromosome: 16 Locus: - |
Gene position | | 28518155 - 28510683 Map Viewer |
Gene orientation | | minus |
Gene size | | 7473 bp |
Gene sequence |
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OMIM ID | | 608273 |
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