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Gene information for RASGRP3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID25780
Official gene symbolRASGRP3
Full nameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases,GRP3,KIAA0846,
Gene summaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM]
LocationChromosome: 2   Locus: 2p25.1-p24.1
Gene position33661416 - 33789798  Map Viewer
Gene orientationplus
Gene size128383 bp
Gene sequence
OMIM ID609531