Entrez gene ID | | 25780 |
Official gene symbol | | RASGRP3 |
Full name | | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | | ,GRP3,KIAA0846, |
Gene summary | | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2p25.1-p24.1 |
Gene position | | 33661416 - 33789798 Map Viewer |
Gene orientation | | plus |
Gene size | | 128383 bp |
Gene sequence |
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OMIM ID | | 609531 |
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