Entrez gene ID | | 25801 |
Official gene symbol | | GCA |
Full name | | grancalcin, EF-hand calcium binding protein |
Aliases | | ,GCL, |
Gene summary | | This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q24.2 |
Gene position | | 163200583 - 163219149 Map Viewer |
Gene orientation | | plus |
Gene size | | 18567 bp |
Gene sequence |
| |
OMIM ID | | 607030 |
|