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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UPF2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID26019
Official gene symbolUPF2
Full nameUPF2 regulator of nonsense transcripts homolog (yeast)
Aliases,DKFZp434D222,HUPF2,KIAA1408,MGC138834,MGC138835,RENT2,smg-3,
Gene summaryThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq]
LocationChromosome: 10   Locus: 10p14-p13
Gene position12085023 - 11962021  Map Viewer
Gene orientationminus
Gene size123003 bp
Gene sequence
OMIM ID605529