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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LAT (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 27040 Official gene symbol LAT Full name linker for activation of T cells Aliases ,LAT1,pp36, Gene summary The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] Location Chromosome: 16   Locus: 16p11.2 Gene position 28996147 - 29002104  Map Viewer Gene orientation plus Gene size 5958 bp Gene sequence >LAT:28936147..28942104:Length=5958 GGGCCTCCCTGCTCGCTGCCTCCCCGGGTCCTGGATATGGAGGCCACGGCTGCCAGCTGG CAGGTGGCTGTCCCCGTCTTGGGGGGGGCCAGCAGACCCTTGGTGAGTGCCTGGGGTGGC TCCCGGGCCTCCTCCTGCCCCCTCCCCACTGGCGGGTGGGGTGGGAAGGGGGCGGGTGCA GCCGGCTGAGAGCTTGATGATTTCCTGCCCTCGCCCGGCGCTCACCACAGCTTCCTGCCG CAGGCGGGCGGGAGGGCGGGCACGGAGAGGCGGGCGCCGAGGAGGGGCAGGTAGGGCTGG GACGCAGGGGTAACTGGATCCCCCGACTTCAGCCCAGGCCCTGGTCTGACCACCCTGGGA GCAGGGACTTTCCACAGTCAGCTGGACGCACACTCAGCCCAGTAAAAGAGGGGACCCATC CCGGGAGCCCCGGGGAGGGCACAGCTGCCTCCTCCCGGGCTCCCCTGCCACCTGGTGCCT ACCTGCCCCCTGCTCCCTGCCGGGTCCGGTCCTCACCCCATCTTCATCTGGCCTTGACTC TGCCCTTGAGGGGCCTAGGGGTGCAGCCAGCCTGCTCCGAGCTCCCCTGCAGATGGAGGA GGCCATCCTGGTCCCCTGCGTGCTGGGGCTCCTGCTGCTGCCCATCCTGGCCATGTTGAT GGCACTGTGTGTGCACTGCCACAGACTGCCAGGTGAGTGGGAAACTGGTGGGGGTACCCA GGGCCCAGGGACACCGACGGGATCCTCATCCACTCCCAGCCCCTGTGTCTGTCCTGGCTC TGTCCCTGCCTCCGTCCTGATCCCAGCGCCTCTGAGAGTCCCTGGATCCCAGCACCTTCT GCCCTAAGCACCCCCTGTTCCTGCCTCACCAGCCCTCTCTTTCCCAGGCTCCTACGACAG CACATCCTCAGATAGGTGAGTCCGCCCCAGCCGCCCTGGGTCTCCCTCCACACCCCATGG CGGGGCAGGGCTGGGGCTTCCATCCTCCATCTTCCAGCCCCATCCCCAAGCTGTGTCTCC TTTACCAGTTTGTATCCAAGGGGCATCCAGTTCAAACGGCCTCGTGAGTACAAGGAGGGT CCCCTACCTTGGGTGCCAGGGAGAGGGTCCCCTGGTGTGGGAGTGAGCGTGAACCTTCAG ACTTCCCCTGCCACCTTGGGGCTGCCCACATGGCCTTGACCTGAGCTGGGAGAGGGGAGA TGGCTCCCCCAGGCCTGTCCAGGGTGTGGGGCTTTCAGGGGCTTAGTCTGTTCTTTGAGG CCTTGACGATGTCCGGAGTCCTTCTTTCAACTTGGTTCTGTGTCCTCAGACACGGTTGCC CCCTGGCCACCTGCCTACCCACCTGTCACCTCCTACCCACCCCTGAGCCAGCCAGACCTG CTCCCCATCCCGTGAGTAGCTGCTCAGCCCCTGCCCCTCCAAAGCTCAGCCCCTCCCCCT CCAAACTCCACTCTCTACCCCTTCACTTTTTTGGATTGGGGGCCCCTTTCCCTTTTGCAA CTGCTGTTGCCCCCTGAGCCCCACCTCAGGCATGACCCCTGACCTTTGACTCCCAGAAGA TCCCCGCAGCCCCTTGGGGGCTCCCACCGGACGCCATCTTCCCGGCGGGATTCTGATGGT GGTAAGTGTGGGGAAGGGTTCAGGCGGCGGGGGCTGGGAAGAAGATAGGCCTGGCCTGAG CTGACTTAGTCTCCCTCTCACCCTCTCTTTGAAGCCAACAGTGTGGCGAGCTACGAGAAC GAGGGTGCGTCTGGGATCCGAGGTGCCCAGGCTGGGTGGGGAGTCTGGGGTCCGTCCTGG ACTAGGCTGACCCCTGTGTCGTTACCCCCAGAACCAGCCTGTGAGGATGCGGATGAGGAT GAGGACGACTATCACAACCCAGGCTACCTGTGAGTGGCCAGGTGGGAGGTGGGAGGTGAG GGCTGAGGCTGTGCGTCCCCCCTTGCTCACCGGCCCTTTTCACTTCCTTTCAGGGTGGTG CTTCCTGACAGCACCCCGGCCACTAGCACTGCTGCCCCATCAGCTCCTGCACTCAGCACC CCTGGCATCCGAGACAGTGCCTTCTCCAGTGAGTCAGGCATTTGTTTTTATTTTTAAATT TTTTTAGGGATAGGCTGGAGTGCAGTGGTGCCATTGTAGCTCGCTGCAGCCTTGAACTCC TGGGCTCCAGTGATCCTCCCAAGTAGGCTACTCGGCCTCAGCCTCCCAAGTAGCTGAGAC CACAGGCGCATGCCACCACACCTAGCTTATTTAAAAAATTTTTTTTGTAGAGATGGTCTC ACTATGTTGCCCAGGCTGGCCTTAAACTCCTGGGCTCAAGTGATCCTCCCACCTCGGGCT CCCAAAGTGCTTGGGATTATAGGCGTGAGCCACCATGCCCGGCCCTGTTCTTCTGATTTT CTCAGCTTTCTCTCTCTTCTTTCCTATCTCTGTGTCCTTTCCTTTATCATCTGGGAGATT TCCTTGTCTGTATTCTTCAACCCTTCCACTGCAATTTTATTTCTCCTATCCAGAAGCTCT TTCTCGTTCTCTGGCTGTTCTTTTTTTATAGCCTCCTGTTCTTGTTTCATGGATGAAACA TCTCTAAGGATGTTAATTAGAGGCTGTCTTGTGTGTCTGTGTGTGTCAGTTTTCTTCTGC TTCCTGCACTGCCCTGTTTCCTTTGAGCTGGTTTTCTCCCTTCCTCATGGTCTCATCCTG CCTGGTCACATCCTCTGGGCTTTCCTCAATGTCCGGGATTCTTTAGTTTTCTGTTGCTTT GCTCTCTCTGTATATACTTGTCCTGGGCTATCACTTCTATACCCTGGCTTTGTTTGCCAT CCAGATTCCCAGTTTGCTCTCTCCTGAGCTCCAGACTGTATCCAAGTACTTCTTTTCTTT CATTCATTCATTCATTCATTCATTCAGCATTTACTATGTGCCTCTGCTGGGCTAATGCTG TGGATATAACAGTTAAGGAGGCAGACTGTCCTGATAAAATAGCTGGCTGGGCATGGTGGC TCACTCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCGGGAGGATTGCTTGAGCCCAGGA GTTCAAGACCAGCCTGAGCAACATGGCGAAACCTCATCTTTAAAAAAAAAAAAAAAATTA GCCAAGCGTGGTGGCACATGCCTGTAGTCCCAGCTGCTCAGGAGGCTGAAATGGGCGGAT CATCTGAACCCCGCAGGCGGAAGTTGCAGTGAGACGAGATCATGCCACTGCACTCCAGCC TGGGTGACAGAGTGAGACCTTGTGTTAAAAAAAAAAAAAAAAGATAAAATAGCTAAGATT CACCGAGGGCCTCCTGCATGCCTTGCTAAGAGTCTGACATGTGTTCACTCACTAATCTGA CTGCCCTGGGGCTCCCGGGCCTGCCCGCGCCCTCCTGTGCTCCAGTTGTCCCTTTTGTGG GATACAGGGTTTATCTGTTTAACAGCACTGCTGTGTGACAGGCCCTATTTTACAGAGGAG AAAACTGAGGCACAGAGAGGTAAGGTCCCTTGGCTGAGGTTATGTGGTTGGTTAGTGCTG GAGCTGGGATTGAACCGGGGCGGTCTTCAAAAACAAACAAGAAACACATAAAAGAACCAA ATAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGG GGATCACCTGAGGTCAGGAGTTCGAGACTGACCTGGCCAACATGGCGAAACCCAGTCTCT ACTAAAAATACCAAAATTAGCAGGGCGTGGTGGCGGGCACCTGTAATCCCAGCTACTCAG GAGGCTGAGGCAGGAGAATTGCTAGAACCGGGAGGCAGAGGTTGCAGTGGGCCAAGATCA CCCCACTGCCCTCCAGCCCTCTAGGTGACAGAGGGAGACTCCATCTCAAAAATAAATAAA TAAACAAAATAAAAGAACCAAATAACCAGGCGTGGTAGCTGATGCCTGTGATCCCAGCAC TTTGGGAGGCTGAGGCAGGTGGGTCACTTGAACCCAGGAGTTCAAGACCAGCCTGGGCAG CATAGGGAGACCCTATCTCTACAAAAATTCCAAAATTTAGCCTGGCCTGGTAGGAGCTGA GGTGGGAAGATCATCTGAGCCCAGGAGGTCAAGGTTGCGGTGAGCCGAGATTGCACCACT GCACTCCAGCCTGGGTAACAGAGCGAGACCCTGTCTCAAGAAAAACAAAAACAAACAAAA AGCTCCCAAATAACATGGATGGTGACAGGCGCCATGAAGGGCTGACATGGGAGTGAGACA TAGGCAGTGGCTGGCAGGGGGCAGGTGGGGATGGGGGTCGGGGGGAGGAGGTGCCTGCTG GGCCTAGTGTGTCATGTCCCCTCCACACACGCCACCAAACTCCCACTGCTCCGAGCCGCA CTACATCCCTGCTCCCCAGCCTAGGGGCTGTGCTGGGGCCTGACCCTTTGTGAGCTCTCC TCAGTCCCAGTCAAGTGGACCTCCTCCCTCCCTCTCCACAGCCCTTGCCCTTGTCCAGGC CACCATCACCATCACCAACACCATCCTTGCCAGCCTGGAGTCCCCTCTCTTCATTCTGTG GGGCTAATGGGGGTGGCTGTGTGGGAAGCCTCTGGGGTCTACCGTTGGGGAGCTCTGCAT GGCTGAGGTTGGGGGTTCTCTGGGAACCTGTGGCCAAGGGTCTCTGGTCACAGTGCCGAG GTGGGCCTGGCTTTTCCACAGTGGAGTCCATTGATGATTACGTGAACGTTCCGGAGAGCG GGGAGAGCGCAGAAGCGTCTCTGGGTGAGTGACCGGTGCTTGTCGGTGCCTGCCCCTGCA CCCCGCTGCCCCACCATGCTCTCAGTGTGACCAGATCCCACCCTGGGGCTACCCACACCC TCTGCCCCCTCTGTCTGGGCGTCCCCTTGCTCTCTCGCCCTCCTGACCCCTTTGCGTGGC TGCCCCTCCTTCTGATCTGTCCCCACAGATGGCAGCCGGGAGTATGTGAATGTGTCCCAG GAACTGCATCCTGGAGCGGCTAAGACTGAGCCTGGTGTGTTCTGCGGGAGGGGCAGGAGC TGGGGTAGCTGCTTTGGGCTTGGGGGGATAGCTTGCAAGCTGGAGACCAACCTCCCCTCC CTTACAGCCGCCCTGAGTTCCCAGGAGGCAGAGGAAGTGGAGGAAGAGGGGGCTCCAGAT TACGAGAATCTGCAGGAGCTGAACTGAGGGCCTGGTGAGAGGCCTGCCCTGTCCCCACCC TGCCCTGGGCCCACAGGCTCTACTCCTTCCCTCCAGGACCCCCTTGCCCAACCCTACCTC TGGCTTGTCCCTCTGTCTCTGGGTACCTGCTGAACCCCGTCAGCCTCCTGATCCGTATCC CTCCCTGCCCTGGTGTGTTTCAGTGGAGGCCGAGTCTGTCCTGGAACCAGGCTTGCCTGG GACGGCTGAGCTGGGCAGCTGGAAGTGGCTCTGGGGTCCTCACATGGCGTCCTGCCCTTG CTCCAGCCTGACAACAGCCTGAGAAATCCCCCCGTAACTTATTATCACTTTGGGGTTCGG CCTGTGTCCCCCGAACGCTCTGCACCTTCTGACGCAGCCTGAGAATGACCTGCCCTGGCC CCAGCCCTACTCTGTGTAATAGAATAAAGGCCTGCGTGTGTCTGTGTTGAGCGTGCGTCT GTGTGTGCCTGTGTGCGAGTCTGAGTCAGAGATTTGGAGATGTCTCTGTGTGTTTGTGTG TATCTGTGGGTCTCCATCCTCCATGGGGGCTCAGCCAGGTGCTGTGACACCCCCCTTCTG AATGAAGCCTTCTGACCTGGGCTGGCACTGCTGGGGGTGAGGACACATTGCCCCATGAGA CAGTCCCAGAACACGGCAGCTGCTGGCTGTGACAATGGTTTCACCATCCTTAGACCAAGG GATGGGACCTGATGACCTGGGAGGACTCTCTTAGTTCTTACCTTTTGTGGTTCTCAATAA AACAGAACTTAAAAAATT OMIM ID 602354