Home

Search

Browse

RAGs

User guide

FAQs

Links

Questions

Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SIGLEC8 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 27181 Official gene symbol SIGLEC8 Full name sialic acid binding Ig-like lectin 8 Aliases ,MGC59785,SAF2,SIGLEC-8,SIGLEC8L, Gene summary Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM] Location Chromosome: 19   Locus: 19q13.33-q13.41 Gene position 51961708 - 51954251  Map Viewer Gene orientation minus Gene size 7458 bp Gene sequence >SIGLEC8:complement(24222469..24229926):Length=7458 AGTTTCTGAGAGAAGAACCCTGAGGAACAGACGTTCCCTGGCGGCCCTGGCGCCTTCAAA CCCAGACATGCTGCTGCTGCTGCTGCTGCTGCCCCTGCTCTGGGGGACAAAGGGGATGGA GGGAGACAGACAATATGGGGATGGTTACTTGCTGCAAGTGCAGGAGCTGGTGACGGTGCA GGAGGGCCTGTGTGTCCATGTGCCCTGCTCCTTCTCCTACCCCCAGGATGGCTGGACTGA CTCTGACCCAGTTCATGGCTACTGGTTCCGGGCAGGAGACAGACCATACCAAGACGCTCC AGTGGCCACAAACAACCCAGACAGAGAAGTGCAGGCAGAGACCCAGGGCCGATTCCAACT CCTTGGGGACATTTGGAGCAACGACTGCTCCCTGAGCATCAGAGACGCCAGGAAGAGGGA TAAGGGGTCATATTTCTTTCGGCTAGAGAGAGGAAGCATGAAATGGAGTTACAAATCACA GTTGAATTACAAAACTAAGCAGCTGTCTGTGTTTGTGACAGGTAAGGCACGGGCTCCAGC ACAGGCCACAGGGGAAGGTCATGAGGGGCTGAAAGGCAGGGCTGGGATGGGGCCTGGGAG GGGGTTGGGATTGAAATAAGTCGGTCTCCGGGGAGGAGCTGGACCAGAGCTTGAGCTTCC TCCAGGGCTGCACCTGAAATACCTCCTCCTGATCCTGTGTCCCCATCTTCACCAGCCCTG ACCCATAGGCCTGACATCCTCATCCTAGGGACCCTAGAGTCTGGCCACTCCAGGAACCTG ACCTGCTCTGTGCCCTGGGCCTGTAAGCAGGGGACACCCCCCATGATCTCCTGGATTGGG GCCTCCGTGTCCTCCCCGGGCCCCACTACTGCCCGCTCCTCAGTGCTCACCCTTACCCCA AAGCCCCAGGACCACGGCACCAGCCTCACCTGTCAGGTGACCTTGCCTGGGACAGGTGTG ACCACGACCAGTACCGTCCGCCTCGATGTGTCCTGTGAGTGCTGGACCAAGATGCCCAGG TCCCTCATGGGTTGGGAGGTGTTCCTGAGGGCAGGGGATGGGGTTCAAGCCTGGACACTG GGTTCTGGGTCCCAGAATCTGGGCTGGGAGTGGGGTCAGGAGAATGCCGACTCCATTTTC CCTGTATTTGCAGCTCCTGGGAAGACAGGGCCAATGTCCCCAGTCCTTATAGTAATGTGG GTCTTCATGTCTTTCTGTCCCAGACCCTCCTTGGAACTTGACCATGACTGTCTTCCAAGG AGATGCCACAGGTAGGACAGAGCCCCCTCCCTGGGGTTGGGGGAGCAGGGCCTTCAGCTC AGGATGGGGCTGGGTCTCTCCTCATCCTGGAATCACTTTGGGAAACAGAGCTGCCACTGT GCGTGAGCCCAGGGCACAAGAGCCCACATCTCCAGCCCGCGTGACCATCTGAGCCCCTGT CCCCATCCTGTCCCTGCTCCCCTTAGACTCCTCCACACACCCCTTCCTTGGCCCCACAGC AAGGACAGGGTGACATTCACACAGCTGGATCAGACTCCCAATTTTTTTGGTTTTTGTTCG TTTTTATTTTGGGACCAGACTTTCAAGTTTCTTGTCAGGCATCTCCTGAATACTTCCTCT GTCTGATCTTTCTGTTTTCCCAGTAGTTTCGATCTAAGTACTTCTGCCCAGATGATACAG TCACATGGGCAGAAATTCAAAATGCACAGCAAAGTCTGTCCTCCAGTGCCCATCCCCCTC CACGGAACTGACCAGCGTCCGTCCAGGCTGCCCTGAGTCTTGGTTTGTGCACCTGGAGGA TCTCAGAGGTGGTTTGACATCGTAGTGAGACTGTCCACCCCGTCCTCTAGGACCGTGTGT GATTTCACTGCACAGATGGACTCTGACTTTGTGGCATCCCTTAAGGAAAATCATGGCACA AATATCCTTCCGCAGAAACTGTGCAGTGGATAGTCTTGTATCTACTTCCACAGGAATATC TAAGTGTATGGGATAAATTCCTAAAAGCAAAATATACCAGTGTCGTATGTTGTTTCTAAT TTTGAAAGATGCAGTGAAGTTGTTCTCAATTAAAAGTGGACAAGTTTACATTCCCAGCAC TGAGTGTGCGTTTTCCTGCACTTCAGTCTATGTCTGTGTGTCAGTCCCTCTCACTAGTCT CTTTCTGTGTCCTTCCTCTTTCTCTGGATCCATTTGTCTCTCTGACCCTCTGTCTCCTTT TATTATTATTATTATTATTATACTTTAAGTTTTAGGATACATGTGCACAACGTGCAGGTT TGTTACATATGTATACATGTGCCATGTTGGTGTGCTGCCCCCAGTAACTTGTCATTTAGC ATTAGGTATATCTCCTAATGCTATCCCTCCCCCCACCCCACAACAGTCCCCGGTGTGTGA TGTTCCCCTTCCTGTGTCCATGTGTTCTCATTGTTCAGTTCCCACTTATGAGTGAGAACA TGCGGTGTTTGTTTTTTTGTCCTTGCAATAGTTTGCTGAGAATGATGGTTTCCAGCTTCA TCCATGTCCCTACAAAGGACATGAACTCATCATTTTTTGTGGCTGCATAGTATTCCATGG TGTATATGTGCCACATTTTCTTAATCCAGTCTATCATTGTTGGACATTTGGGCTGGTTCC AAGTCTTTGCTATTGTGAATAGTGCCACAATAAACATACATGTGCATGTGTCTTTATAGC AGCATGATTTATAATCCTTTGGGTATATACCCAGTAATGGGATGACCCTCTGTCTCTTTC TCTGCAGCATCCACAGCCCTGGGAAATGGCTCATCTCTTTCAGTCCTTGAGGGCCAGTCT CTGCGCCTGGTCTGTGCTGTCAACAGCAATCCCCCTGCCAGGCTGAGCTGGACCCGGGGG AGCCTGACCCTGTGCCCCTCACGGTCCTCAAACCCTGGGCTGCTGGAGCTGCCTCGAGTG CACGTGAGGGATGAAGGGGAATTCACCTGCCGAGCTCAGAACGCTCAGGGCTCCCAGCAC ATTTCCCTGAGCCTCTCCCTGCAGAATGAGGGCACAGGTGGGTAAGGGAGGGGCTGGAGG AGGAGAACACACCTGCCCCACCCTCATGGACCACCCACTGCCCCTGAGCTTCAAGGGGGA GCTCAGCTCTGGTCTGTGCTCAGCTGTGAGGCCTGGAACTTCCCTGCGACCCAGAGCATC ACTGTCCTCTCCCCGCCAGGAAAGGGGTGCGGGGTGGGGAGAGGGGAGGAGTGGGTCTTG GAGGGGAGGAGCTGGGGCCCGGCCAGGTGTGTTTGGAGGGACAAGCGCCTTGCTTTGCAG TGCTTAGACTAGGATGAGGCACATGAGGCACTTGCCTTGGCACCAAATTTAAGAAGCCAA AGAAAAACCCAACTCAGAAAGCAAGTAAAGTAATATTGCAATGCCATGATCTTTTGAAAA AACTAAAATTGAATGCAAAATGATTCCACAAGAACACAATATCAAAATTGTAAATAAAGG CAAGACAAGCTGCATCCAGCACTCTCATGCCTCACTGGCCTCAGAAGTAGTCTCCTTTCC TCCCTCCCATTCGTATTCTGTGTCTGGGAAGGAGAAGAGGGGAATGGAAGTCTAGGGCCC TGCAGACAGTGGGAGGGGAAGAGACCCACTTCTCCGTGATATAAATCCCCAAAGCAACTC CAATCCATCTGCAGGCACCTCAAGACCTGTATCACAAGTGACACTGGCAGCAGTCGGGGG AGCTGGAGCCACAGCCCTGGCCTTCCTGTCCTTCTGCATCATCTTCATCATGTGAGCATT GACCCTGGGGAGGGAGAGAGAGACCTGGGGCAGGGCAGACCGGGAACAGAATCCCTGAAG CCAGAGCTGGAAGGACCTGGATGGGTCCAGGGCTTGGGGCAAGAATGAGCTCACGGGTGC ACGGTGAGCATTTCACGAGCGTCCTTGTCTGTGGGGCTCCACATCTGTAGCAACCTCGGG CCCCACCATCCATGAGGCAGGAGCCTCTGTTTTCACCGTTGGGGTCTCTGGAACTGGACC ACCGCCGTTGCGCCTCGGTCACCCCTCAAGCCCCCAGTAGGAAATACAGGGCAGGGGTTG GTCTGCCCACTGCACCCCGATCTGACCACACTGAAAGGCTCTCTGGTCTCTTCACTCAGA GTGAGGTCCTGCAGGAAGAAATCGGCAAGGCCAGCAGCGGGCGTGGGGGATACAGGCATG GAAGATGCAAAGGCCATCAGGGGCTCGGCCTCTCAGGTGAGTGATGTGGGCTTCTCCACA CCGAGCATCCAGCCTGGACACCTCTGACAGGATGGCCCCCAGGATCGCTCTCTTTGGTAT GGCCAAAGTCACTTCCTCGTCTCCTCCTCCTTCCCACAGGCCGGCTTCTACAGGACTCCC CCATCTTGCTGACAGCATGGCAGTCCCTACCCCCAATTTTTCCCAGGCCAGGCACTGAGT AGGAGTTATCTCCTCTCTGTCCTCCTTTTCTTCTCTATAGCCCCGATTCACCATCTCTCC TCCATTTTTCCTCCCCAAGAATAGCTGGCATCTCTTCTCCCTGGCCCCAGCCATCCTGAC CCCTCTCATTATTTTTCCTATTGGCGGGACCTGATTTCTTTGACCGGCTTGTCATCCTTA CGCCACTAACCTGTGAGCTTCCCCAGGTCAGGTATCATGTCTCAATTAAGGCCCTGTAAT TCTCTCTCATTTACTCTCGTTTTGCCCGTTGTATCATAATTTACATGTAGATACTCATTT CTTATTTTTATTTTTTTCTCGAGGCAGAATCTTGCTCTGTCACCTAGGCTGGAGTGCAGT GGGGCAATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCA GCCTCCCAAGTAGCCAGGATTACAGGCACGCGCCACCAAGCCAGGCTAATTTTTGTATTT TTAGTAGAGACGGGGTTTCACCATGTCGGCCAGCTGGTCTCGAACTCCTGACCTCGTGAT CCGCCCGCCTCAGCCTCCCAAAGTGTTAGGATTAGGGGCATGAGCCACCGCACCCAAGCT GATATTCATTTCTTTAACAGTCATTTGTTGCCACCTCCCTCAATTAAAGACTGAGCTGCC ACTTTGGGAGGCCAAGGTAGGAGGATCGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGC AACATAATGAGATCCCATCTCTACAAAAAAATGCAAAACTTAACCAGGCATGGTGGTGAG TTCCTGCAGTCCCAGCTACTTGGGGGGCTGAGATGGAATGATCCCTTGAGCCCAGGAAGT GGAGGGTGCAGTGAGCTGGGATTGCACCACTGCACTCCAGCCTGGGCAACAGAGCCAGAC TCTGTCTCAAAAAAAAAACCAAAAAACAAAACAAAACAAAACAAAAACTGAGCTGCAGGA GGTCAGGGCCCACACCTACCATGTCCATCATAGTTTATCCAGCACCGGCTCAGGGCCTCA CACACGGGGGCCTCAGCAGGACTCCAGGCTTTGGGGTCAGAAGGAACAGATGGATTGGGT CCTGCTGCAACAGGGACTTTGGGCGCAGTGCTGACTGTTTCGACCTCAGTTTTCATATTT ATAAAGTGGAGATAATAATAATATCTCACTATGGAGTTGTTGCGGGAAGTTAATGAGATT AGTAAACACCAAACAGGTGCTCAGTAAGTGTTAAATGTTGGAGGAAAGCATGAAAGACAC TTCGACAAAAATGCAGGTGGGATGAATGGAGGACGGACCTCCTGGGCCTCCTTCCTGGAC TCTCCCTGCCTCATCCTGGCCCCACTGCTCTGTTCTGACTCCCTTCTCTCTCTCTGTCCA GGGACCCCTGACTGAATCCTGGAAAGATGGCAACCCCCTGAAGAAGCCTCCCCCAGCTGT TGCCCCCTCGTCAGGGGAGGAAGGAGAGCTCCATTATGCAACCCTCAGCTTCCATAAAGT GAAGCCTCAGGACCCGCAGGGACAGGAGGCCACTGACAGTGAATACTCGGAGATCAAGAT CCACAAGCGAGAAACTGCAGAGACTCAGGCCTGTTTGAGGAATCACAACCCCTCCAGCAA AGAAGTCAGAGGCTGATTCTCATAGAACAAGAACCCTCTAGAGCCCCATGCTATGCAGTA GGTCACCAGGGCTCCCTCCTCCTGTCTAACCAAAACTTGGACCAATGTCTCCCCTTTCCC CGGCTACCAGGGACCCATCCCTGCCTCTAGCTTCTACTACCCACCATTCTCCTCTCGACC TCTCTGAGGTTGACTATTTTAGATTCCACATAGAGATGAGGTCATGTGGTACTTGCCTCT CTGTGTGTGGCTCATTTTACACAAAAAAATATCCCCTAGGTTCATCCATGTTCTCTCAAA TGACAGAATCAAGCACTGAATATTTTTTTTTCTTTGAGAGATGGAGTTTCGCTCTGTTGC CCAGGCTGGAGTGCAGTGGTTCAATCTCTGCTCACTGCAACCTCCACCTCCTGGGTTCAA ACGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGTACTACAGGCGTGTGTCACCACGCCC AGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACTATAAGTGGGCCAGGCTAGTC TCAAACTCCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTTCAG GCATGAGCCACCGCACCCAGCTTGCATTGAATATTTTCAAGGAGCTAAAAGAAGATTTTA AATGGTCTCACAAAAACAGATAAATATTTGCACAGATGGGTGTGCTAATCATTGTGCCTT GATGGTTCCACGATGTATCCGGGTGTGGAAATCTCACTGGGTCTCTCTCAAGGCCACTCG GCTACTCAGGACAGGGCTGGAATTTAAAGCCTGTCCGATTCTGAGGTCTCTTCTCTCATC TAGCACTGAGTCAAGCAATCAGCAGGCTGGGCACCCCTTAGCCATAAGTTTTCAGGAAAT AAATTCCTTGAGGGCATTGACTTTTACAAAAGAGGGAGCAGCAATGGCCTAGAGTCTCAG GAACAAGACAGGTGCACTGAGGAGATGAAGGCCGGGACCCCCTGCCCAACCTGTATGGCG GGTCTGTACTTATTTTGTTTACCCCCAATTTAAAACGTTTTTTTTTATTGCAGGTTGTTT GTTTGATATGGTTTGGCTGTGTCCCCACCCAAATCTTATCTAGAATTGTAATCAGAATTA TAATCCCCATGTGTTGGGGGAGGGACCTGGTGGGAGGTGATAGGATCATGGGGGTGGTTC CCCCATGCTGTTCTGATAGTGAGTGAGTTATCACGAGATCTGATGGTTTTGTAAGTGGTG GTTTCCCCTGCTCTTCTCTCTTGCCTGCCACCATGTAAGATGTGCCTGGTTCCCCTTCCG CCATGATTGTAAGTTTCCTGAGGCCTCCCCCGCCATGTGGAACTGTGAGTCAATTACACC TCTTTCATTTATAAATTA OMIM ID 605639