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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GPC3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2719
Official gene symbolGPC3
Full nameglypican 3
Aliases,DGSX,GTR2-2,MXR7,OCI-5,SDYS,SGB,SGBS,SGBS1,
Gene summaryCell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: X   Locus: Xq26.1
Gene position133119673 - 132669773  Map Viewer
Gene orientationminus
Gene size449901 bp
Gene sequence
OMIM ID300037