Entrez gene ID | | 2731 |
Official gene symbol | | GLDC |
Full name | | glycine dehydrogenase (decarboxylating) |
Aliases | | ,GCE,GCSP,HYGN1,MGC138198,MGC138200, |
Gene summary | | Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). |
Location | | Chromosome: 9 Locus: 9p22 |
Gene position | | 6645692 - 6532464 Map Viewer |
Gene orientation | | minus |
Gene size | | 113229 bp |
Gene sequence |
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OMIM ID | | 238300 |
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