Entrez gene ID | | 27329 |
Official gene symbol | | ANGPTL3 |
Full name | | angiopoietin-like 3 |
Aliases | | ,ANGPT5, |
Gene summary | | The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p31.1-p22.3 |
Gene position | | 63063187 - 63071180 Map Viewer |
Gene orientation | | plus |
Gene size | | 7994 bp |
Gene sequence |
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OMIM ID | | 604774 |
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