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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GRID2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2895
Official gene symbolGRID2
Full nameglutamate receptor, ionotropic, delta 2
Aliases,MGC117022,MGC117023,MGC117024,
Gene summaryHuman glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q22
Gene position93225550 - 94693649  Map Viewer
Gene orientationplus
Gene size1468100 bp
Gene sequence
OMIM ID602368