Entrez gene ID | | 28951 |
Official gene symbol | | TRIB2 |
Full name | | tribbles homolog 2 (Drosophila) |
Aliases | | ,C5FW,FLJ57420,GS3955,TRB2, |
Gene summary | | This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p24.3 |
Gene position | | 12856998 - 12882860 Map Viewer |
Gene orientation | | plus |
Gene size | | 25863 bp |
Gene sequence |
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OMIM ID | | 609462 |