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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PYCARD (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 29108 Official gene symbol PYCARD Full name PYD and CARD domain containing Aliases ,ASC,CARD5,MGC10332,TMS,TMS-1,TMS1, Gene summary This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 16   Locus: 16p12-p11.2 Gene position 31214251 - 31212807  Map Viewer Gene orientation minus Gene size 1445 bp Gene sequence >PYCARD:complement(31152807..31154251):Length=1445 GAGGGCGCGATCCTGGCGTCCCCCGACGGCCTGGGGCCCCAATCCAGAGGCCTGGGTGGG AGGGGACCAAGGGTGTAGTAAGGAAGCGCCTTTTGCTGGAGGGCAACGGACCGGGGCGGG GAGTCGGGAGACCAGAGTGGGAGGAAGGCGGGGAGTCCAGGTTCCGCCCCGGAGCCGACT TCCTCCTGGTCGGCGGCTGCAGCGGGGTGAGCGGCGGCAGCGGCCGGGGATCCTGGAGCC ATGGGGCGCGCGCGCGACGCCATCCTGGATGCGCTGGAGAACCTGACCGCCGAGGAGCTC AAGAAGTTCAAGCTGAAGCTGCTGTCGGTGCCGCTGCGCGAGGGCTACGGGCGCATCCCG CGGGGCGCGCTGCTGTCCATGGACGCCTTGGACCTCACCGACAAGCTGGTCAGCTTCTAC CTGGAGACCTACGGCGCCGAGCTCACCGCTAACGTGCTGCGCGACATGGGCCTGCAGGAG ATGGCCGGGCAGCTGCAGGCGGCCACGCACCAGGGTGAGCCGCCCCCGTTCCCCTCCACC CCGTCTTTCCCCTCCACCCACACCAGCGCTTACCCCGCGGGCTCTTCCGCTTTCTGTTCC TCCTACCCCTAAACAAAGCTGCTCTACCGGAAAGGAGGCTCCCCACGCTTGGCCTACCGA CCAACGGGACCCCGGCCCCACGGCGGGAAGGGAAGGGAAGGGGATCACTTGGCCCATATC CTTCCAGGCTCTGGAGCCGCGCCAGCTGGGATCCAGGCCCCTCCTCAGTCGGCAGCCAAG CCAGGTGAGGCCTCCACACCCAGCCCGGCCCCACCGCACTCCTGCACAGCCTGCATCTGT GCTCCCGCAACCAGGGCAGGGCAGGGCAGGGCAGGCACGGCTTGGCAACCCTGCGCACCC CACCCACCAACCCACACCCTGCGGGGGAAGGGAGACAATATTACCCTCATCCCACTGCAT GTGGGGTCCTGGTGGCCGCCCCCTGGAGCCCTGCCCCTAGGCTTGCAGAGGAATTCCTGA AGAACTCAAGTTCAGCAGGGACAGGCCCCACACCCTGGCTGCTGGCTCATGTTCTCCTCC CACCCCCAGGCCTGCACTTTATAGACCAGCACCGGGCTGCGCTTATCGCGAGGGTCACAA ACGTTGAGTGGCTGCTGGATGCTCTGTACGGGAAGGTCCTGACGGATGAGCAGTACCAGG CAGTGCGGGCCGAGCCCACCAACCCAAGCAAGATGCGGAAGCTCTTCAGTTTCACACCAG CCTGGAACTGGACCTGCAAGGACTTGCTCCTCCAGGCCCTAAGGGAGTCCCAGTCCTACC TGGTGGAGGACCTGGAGCGGAGCTGAGGCTCCTTCCCAGCAACACTCCGGTCAGCCCCTG GCAATCCCACCAAATCATCCTGAATCTGATCTTTTTATACACAATATACGAAAAGCCAGC TTGAA OMIM ID 606838