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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GRM1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2911
Official gene symbolGRM1
Full nameglutamate receptor, metabotropic 1
Aliases,GPRC1A,GRM1A,MGLUR1,MGLUR1A,mGlu1,
Gene summaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q24
Gene position146348782 - 146758731  Map Viewer
Gene orientationplus
Gene size409950 bp
Gene sequence
OMIM ID604473