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Gene information for TBK1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID29110
Official gene symbolTBK1
Full nameTANK-binding kinase 1
Aliases,FLJ11330,NAK,T2K,
Gene summaryThe NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q14.1
Gene position64845937 - 64895891  Map Viewer
Gene orientationplus
Gene size49955 bp
Gene sequence
OMIM ID604834