Entrez gene ID | | 2956 |
Official gene symbol | | MSH6 |
Full name | | mutS homolog 6 (E. coli) |
Aliases | | ,GTBP,HNPCC5,HSAP, |
Gene summary | | This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p16 |
Gene position | | 48010221 - 48034092 Map Viewer |
Gene orientation | | plus |
Gene size | | 23872 bp |
Gene sequence |
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OMIM ID | | 600678 |
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