Entrez gene ID | | 30009 |
Official gene symbol | | TBX21 |
Full name | | T-box 21 |
Aliases | | ,T-PET,T-bet,TBET,TBLYM, |
Gene summary | | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q21.32 |
Gene position | | 45810610 - 45823485 Map Viewer |
Gene orientation | | plus |
Gene size | | 12876 bp |
Gene sequence |
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OMIM ID | | 604895 |
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