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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HFE (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3077 Official gene symbol HFE Full name hemochromatosis Aliases ,HFE1,HH,HLA-H,MGC103790,MVCD7,dJ221C16.10.1, Gene summary The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 26087448 - 26097059  Map Viewer Gene orientation plus Gene size 9612 bp Gene sequence >HFE:26027448..26037059:Length=9612 GGGGACACTGGATCACCTAGTGTTTCACAAGCAGGTACCTTCTGCTGTAGGAGAGAGAGA ACTAAAGTTCTGAAAGACCTGTTGCTTTTCACCAGGAAGTTTTACTGGGCATCTCCTGAG CCTAGGCAATAGCTGTAGGGTGACTTCTGGAGCCATCCCCGTTTCCCCGCCCCCCAAAAG AAGCGGAGATTTAACGGGGACGTGCGGCCAGAGCTGGGGAAATGGGCCCGCGAGCCAGGC CGGCGCTTCTCCTCCTGATGCTTTTGCAGACCGCGGTCCTGCAGGGGCGCTTGCTGCGTG AGTCCGAGGGCTGCGGGCGAACTAGGGGCGCGGCGGGGGTGGAAAAATCGAAACTAGCTT TTTCTTTGCGCTTGGGAGTTTGCTAACTTTGGAGGACCTGCTCAACCCTATCCGCAAGCC CCTCTCCCTACTTTCTGCGTCCAGACCCCGTGAGGGAGTGCCTACCACTGAACTGCAGAT AGGGGTCCCTCGCCCCAGGACCTGCCCCCTCCCCCGGCTGTCCCGGCTCTGCGGAGTGAC TTTTGGAACCGCCCACTCCCTTCCCCCAACTAGAATGCTTTTAAATAAATCTCGTAGTTC CTCACTTGAGCTGAGCTAAGCCTGGGGCTCCTTGAACCTGGAACTCGGGTTTATTTCCAA TGTCAGCTGTGCAGTTTTTTCCCCAGTCATCTCCAAACAGGAAGTTCTTCCCTGAGTGCT TGCCGAGAAGGCTGAGCAAACCCACAGCAGGATCCGCACGGGGTTTCCACCTCAGAACGA ATGCGTTGGGCGGTGGGGGCGCGAAAGAGTGGCGTTGGGGATCTGAATTCTTCACCATTC CACCCACTTTTGGTGAGACCTGGGGTGGAGGTCTCTAGGGTGGGAGGCTCCTGAGAGAGG CCTACCTCGGGCCTTTCCCCACTCTTGGCAATTGTTCTTTTGCCTGGAAAATTAAGTATA TGTTAGTTTTGAACGTTTGAACTGAACAATTCTCTTTTCGGCTAGGCTTTATTGATTTGC AATGTGCTGTGTAATTAAGAGGCCTCTCTACAAAGTACTGATAATGAACATGTAAGCAAT GCACTCACTTCTAAGTTACATTCATATCTGATCTTATTTGATTTTCACTAGGCATAGGGA GGTAGGAGCTAATAATACGTTTATTTTACTAGAAGTTAACTGGAATTCAGATTATATAAC TCTTTTCAGGTTACAAAGAACATAAATAATCTGGTTTTCTGATGTTATTTCAAGTACTAC AGCTGCTTCTAATCTTAGTTGACAGTGATTTTGCCCTGTAGTGTAGCACAGTGTTCTGTG GGTCACACGCCGGCCTCAGCACAGCACTTTGAGTTTTGGTACTACGTGTATCCACATTTT ACACATGACAAGAATGAGGCATGGCACGGCCTGCTTCCTGGCAAATTTATTCAATGGTAC ACTGGGCTTTGGTGGCAGAGCTCATGTCTCCACTTCATAGCTATGATTCTTAAACATCAC ACTGCATTAGAGGTTGAATAATAAAATTTCATGTTGAGCAGAAATATTCATTGTTTACAA GTGTAAATGAGTCCCAGCCATGTGTTGCACTGTTCAAGCCCCAAGGGAGAGAGCAGGGAA ACAAGTCTTTACCCTTTGATATTTTGCATTCTAGTGGGAGAGATGACAATAAGCAAATGA GCAGAAAGATATACAACATCAGGAAATCATGGGTGTTGTGAGAAGCAGAGAAGTCAGGGC AAGTCACTCTGGGGCTGACACTTGAGCAGAGACATGAAGGAAATAAGAATGATATTGACT GGGAGCAGTATTTCCCAGGCAAACTGAGTGGGCCTGGCAAGTTGGATTAAAAAGCGGGTT TTCTCAGCACTACTCATGTGTGTGTGTGTGGGGGGGGGGGGCGGCGTGGGGGTGGGAAGG GGGACTACCATCTGCATGTAGGATGTCTAGCAGTATCCTGTCCTCCCTACTCACTAGGTG CTAGGAGCACTCCCCCAGTCTTGACAACCAAAAATGTCTCTAAACTTTGCCACATGTCAC CTAGTAGACAAACTCCTGGTTAAGAAGCTCGGGTTGAAAAAAATAAACAAGTAGTGCTGG GGAGTAGAGGCCAAGAAGTAGGTAATGGGCTCAGAAGAGGAGCCACAAACAAGGTTGTGC AGGCGCCTGTAGGCTGTGGTGTGAATTCTAGCCAAGGAGTAACAGTGATCTGTCACAGGC TTTTAAAAGATTGCTCTGGCTGCTATGTGGAAAGCAGAATGAAGGGAGCAACAGTAAAAG CAGGGAGCCCAGCCAGGAAGCTGTTACACAGTCCAGGCAAGAGGTAGTGGAGTGGGCTGG GTGGGAACAGAAAAGGGAGTGACAAACCATTGTCTCCTGAATATATTCTGAAGGAAGTTG CTGAAGGATTCTATGTTGTGTGAGAGAAAGAGAAGAATTGGCTGGGTGTAGTAGCTCATG CCAAGGAGGAGGCCAAGGAGAGCAGATTCCTGAGCTCAGGAGTTCAAGACCAGCCTGGGC AACACAGCAAAACCCCTTCTCTACAAAAAATACAAAAATTAGCTGGGTGTGGTGGCATGC ACCTGTGATCCTAGCTACTCGGGAGGCTGAGGTGGAGGGTATTGCTTGAGCCCAGGAAGT TGAGGCTGCAGTGAGCCATGACTGTGCCACTGTACTTCAGCCTAGGTGACAGAGCAAGAC CCTGTCTCCCCTGACCCCCTGAAAAAGAGAAGAGTTAAAGTTGACTTTGTTCTTTATTTT AATTTTATTGGCCTGAGCAGTGGGGTAATTGGCAATGCCATTTCTGAGATGGTGAAGGCA GAGGAAAGAGCAGTTTGGGGTAAATCAAGGATCTGCATTTGGACATGTTAAGTTTGAGAT TCCAGTCAGGCTTCCAAGTGGTGAGGCCACATAGGCAGTTCAGTGTAAGAATTCAGGACC AAGGCTGGGCACGGTGGCTCACTTCTGTAATCCCAGCACTTTGGTGGCTGAGGCAGGTAG ATCATTTGAGGTCAGGAGTTTGAGACAAGCTTGGCCAACATGGTGAAACCCCATGTCTAC TAAAAATACAAAAATTAGCCTGGTGTGGTGGCGCACGCCTATAGTCCCAGGTTTTCAGGA GGCTTAGGTAGGAGAATCCCTTGAACCCAGGAGGTGCAGGTTGCAGTGAGCTGAGATTGT GCCACTGCACTCCAGCCTGGGTGATAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAA AAAAAAAAAAAACTGAAGGAATTATTCCTCAGGATTTGGGTCTAATTTGCCCTGAGCACC AACTCCTGAGTTCAACTACCATGGCTAGACACACCTTAACATTTTCTAGAATCCACCAGC TTTAGTGGAGTCTGTCTAATCATGAGTATTGGAATAGGATCTGGGGGCAGTGAGGGGGTG GCAGCCACGTGTGGCAGAGAAAAGCACACAAGGAAAGAGCACCCAGGACTGTCATATGGA AGAAAGACAGGACTGCAACTCACCCTTCACAAAATGAGGACCAGACACAGCTGATGGTAT GAGTTGATGCAGGTGTGTGGAGCCTCAACATCCTGCTCCCCTCCTACTACACATGGTTAA GGCCTGTTGCTCTGTCTCCAGGTTCACACTCTCTGCACTACCTCTTCATGGGTGCCTCAG AGCAGGACCTTGGTCTTTCCTTGTTTGAAGCTTTGGGCTACGTGGATGACCAGCTGTTCG TGTTCTATGATCATGAGAGTCGCCGTGTGGAGCCCCGAACTCCATGGGTTTCCAGTAGAA TTTCAAGCCAGATGTGGCTGCAGCTGAGTCAGAGTCTGAAAGGGTGGGATCACATGTTCA CTGTTGACTTCTGGACTATTATGGAAAATCACAACCACAGCAAGGGTATGTGGAGAGGGG GCCTCACCTTCCTGAGGTTGTCAGAGCTTTTCATCTTTTCATGCATCTTGAAGGAAACAG CTGGAAGTCTGAGGTCTTGTGGGAGCAGGGAAGAGGGAAGGAATTTGCTTCCTGAGATCA TTTGGTCCTTGGGGATGGTGGAAATAGGGACCTATTCCTTTGGTTGCAGTTAACAAGGCT GGGGATTTTTCCAGAGTCCCACACCCTGCAGGTCATCCTGGGCTGTGAAATGCAAGAAGA CAACAGTACCGAGGGCTACTGGAAGTACGGGTATGATGGGCAGGACCACCTTGAATTCTG CCCTGACACACTGGATTGGAGAGCAGCAGAACCCAGGGCCTGGCCCACCAAGCTGGAGTG GGAAAGGCACAAGATTCGGGCCAGGCAGAACAGGGCCTACCTGGAGAGGGACTGCCCTGC ACAGCTGCAGCAGTTGCTGGAGCTGGGGAGAGGTGTTTTGGACCAACAAGGTATGGTGGA AACACACTTCTGCCCCTATACTCTAGTGGCAGAGTGGAGGAGGTTGCAGGGCACGGAATC CCTGGTTGGAGTTTCAGAGGTGGCTGAGGCTGTGTGCCTCTCCAAATTCTGGGAAGGGAC TTTCTCAATCCTAGAGTCTCTACCTTATAATTGAGATGTATGAGACAGCCACAAGTCATG GGTTTAATTTCTTTTCTCCATGCATATGGCTCAAAGGGAAGTGTCTATGGCCCTTGCTTT TTATTTAACCAATAATCTTTTGTATATTTATACCTGTTAAAAATTCAGAAATGTCAAGGC CGGGCACGGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGTCAC AAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCGTCTCTAAAAAAATAC AAAAATTAGCTGGTCACAGTCATGCGCACCTGTAGTCCCAGCTAATTGGAAGGCTGAGGC AGGAGCATCGCTTGAACCTGGGAAGCGGAAGTTGCACTGAGCCAAGATCGCGCCACTGCA CTCCAGCCTAGGCAGCAGAGTGAGACTCCATCTTAAAAAAAAAAAAAAAAAAAAAAAGAG AATTCAGAGATCTCAGCTATCATATGAATACCAGGACAAAATATCAAGTGAGGCCACTTA TCAGAGTAGAAGAATCCTTTAGGTTAAAAGTTTCTTTCATAGAACATAGCAATAATCACT GAAGCTACCTATCTTACAAGTCCGCTTCTTATAACAATGCCTCCTAGGTTGACCCAGGTG AAACTGACCATCTGTATTCAATCATTTTCAATGCACATAAAGGGCAATTTTATCTATCAG AACAAAGAACATGGGTAACAGATATGTATATTTACATGTGAGGAGAACAAGCTGATCTGA CTGCTCTCCAAGTGACACTGTGTTAGAGTCCAATCTTAGGACACAAAATGGTGTCTCTCC TGTAGCTTGTTTTTTTCTGAAAAGGGTATTTCCTTCCTCCAACCTATAGAAGGAAGTGAA AGTTCCAGTCTTCCTGGCAAGGGTAAACAGATCCCCTCTCCTCATCCTTCCTCTTTCCTG TCAAGTGCCTCCTTTGGTGAAGGTGACACATCATGTGACCTCTTCAGTGACCACTCTACG GTGTCGGGCCTTGAACTACTACCCCCAGAACATCACCATGAAGTGGCTGAAGGATAAGCA GCCAATGGATGCCAAGGAGTTCGAACCTAAAGACGTATTGCCCAATGGGGATGGGACCTA CCAGGGCTGGATAACCTTGGCTGTACCCCCTGGGGAAGAGCAGAGATATACGTGCCAGGT GGAGCACCCAGGCCTGGATCAGCCCCTCATTGTGATCTGGGGTATGTGACTGATGAGAGC CAGGAGCTGAGAAAATCTATTGGGGGTTGAGAGGAGTGCCTGAGGAGGTAATTATGGCAG TGAGATGAGGATCTGCTCTTTGTTAGGGGGTGGGCTGAGGGTGGCAATCAAAGGCTTTAA CTTGCTTTTTCTGTTTTAGAGCCCTCACCGTCTGGCACCCTAGTCATTGGAGTCATCAGT GGAATTGCTGTTTTTGTCGTCATCTTGTTCATTGGAATTTTGTTCATAATATTAAGGAAG AGGCAGGGTTCAAGTGAGTAGGAACAAGGGGGAAGTCTCTTAGTACCTCTGCCCCAGGGC ACAGTGGGAAGAGGGGCAGAGGGGATCTGGCATCCATGGGAAGCATTTTTCTCATTTATA TTCTTTGGGGACACCAGCAGCTCCCTGGGAGACAGAAAATAATGGTTCTCCCCAGAATGA AAGTCTCTAATTCAACAAACATCTTCAGAGCACCTACTATTTTGCAAGAGCTGTTTAAGG TAGTACAGGGGCTTTGAGGTTGAGAAGTCACTGTGGCTATTCTCAGAACCCAAATCTGGT AGGGAATGAAATTGATAGCAAGTAAATGTAGTTAAAGAAGACCCCATGAGGTCCTAAAGC AGGCAGGAAGCAAATGCTTAGGGTGTCAAAGGAAAGAATGATCACATTCAGCTGGGGATC AAGATAGCCTTCTGGATCTTGAAGGAGAAGCTGGATTCCATTAGGTGAGGTTGAAGATGA TGGGAGGTCTACACAGACGGAGCAACCATGCCAAGTAGGAGAGTATAAGGCATACTGGGA GATTAGAAATAATTACTGTACCTTAACCCTGAGTTTGCGTAGCTATCACTCACCAATTAT GCATTTCTACCCCCTGAACATCTGTGGTGTAGGGAAAAGAGAATCAGAAAGAAGCCAGCT CATACAGAGTCCAAGGGTCTTTTGGGATATTGGGTTATGATCACTGGGGTGTCATTGAAG GATCCTAAGAAAGGAGGACCACGATCTCCCTTATATGGTGAATGTGTTGTTAAGAAGTTA GATGAGAGGTGAGGAGACCAGTTAGAAAGCCAATAAGCATTTCCAGATGAGAGATAATGG TTCTTGAAATCCAATAGTGCCCAGGTCTAAATTGAGATGGGTGAATGAGGAAAATAAGGA AGAGAGAAGAGGCAAGATGGTGCCTAGGTTTGTGATGCCTCTTTCCTGGGTCTCTTGTCT CCACAGGAGGAGCCATGGGGCACTACGTCTTAGCTGAACGTGAGTGACACGCAGCCTGCA GACTCACTGTGGGAAGGAGACAAAACTAGAGACTCAAAGAGGGAGTGCATTTATGAGCTC TTCATGTTTCAGGAGAGAGTTGAACCTAAACATAGAAATTGCCTGACGAACTCCTTGATT TTAGCCTTCTCTGTTCATTTCCTCAAAAAGATTTCCCCATTTAGGTTTCTGAGTTCCTGC ATGCCGGTGATCCCTAGCTGTGACCTCTCCCCTGGAACTGTCTCTCATGAACCTCAAGCT GCATCTAGAGGCTTCCTTCATTTCCTCCGTCACCTCAGAGACATACACCTATGTCATTTC ATTTCCTATTTTTGGAAGAGGACTCCTTAAATTTGGGGGACTTACATGATTCATTTTAAC ATCTGAGAAAAGCTTTGAACCCTGGGACGTGGCTAGTCATAACCTTACCAGATTTTTACA CATGTATCTATGCATTTTCTGGACCCGTTCAACTTTTCCTTTGAATCCTCTCTCTGTGTT ACCCAGTAACTCATCTGTCACCAAGCCTTGGGGATTCTTCCATCTGATTGTGATGTGAGT TGCACAGCTATGAAGGCTGTACACTGCACGAATGGAAGAGGCACCTGTCCCAGAAAAAGC ATCATGGCTATCTGTGGGTAGTATGATGGGTGTTTTTAGCAGGTAGGAGGCAAATATCTT GAAAGGGGTTGTGAAGAGGTGTTTTTTCTAATTGGCATGAAGGTGTCATACAGATTTGCA AAGTTTAATGGTGCCTTCATTTGGGATGCTACTCTAGTATTCCAGACCTGAAGAATCACA ATAATTTTCTACCTGGTCTCTCCTTGTTCTGATAATGAAAATTATGATAAGGATGATAAA AGCACTTACTTCGTGTCCGACTCTTCTGAGCACCTACTTACATGCATTACTGCATGCACT TCTTACAATAATTCTATGAGATAGGTACTATTATCCCCATTTCTTTTTTAAATGAAGAAA GTGAAGTAGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAAG CGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCATC TCTAATAAAAATACAAAAAATTAGCTGGGCGTGGTGGCAGACGCCTGTAGTCCCAGCTAC TCGGAAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGCAGTGAGCCGA GTTTGCGCCACTGCACTCCAGCCTAGGTGACAGAGTGAGACTCCATCTCAAAAAAATAAA AATAAAAATAAAAAAATGAAAAAAAAAAGAAAGTGAAGTATAGAGTATCTCATAGTTTGT CAGTGATAGAAACAGGTTTCAAACTCAGTCAATCTGACCGTTTGATACATCTCAGACACC ACTACATTCAGTAGTTTAGATGCCTAGAATAAATAGAGAAGGAAGGAGATGGCTCTTCTC TTGTCTCATTGTGTTTCTTCTGAGTGAGCTTGAATCACATGAAGGGGAACAGCAGAAAAC AACCAACTGATCCTCAGCTGTCATGTTTCCTTTAAAAGTCCCTGAAGGAAGGTCCTGGAA TGTGACTCCCTTGCTCCTCTGTTGCTCTCTTTGGCATTCATTTCTTTGGACCCTACGCAA GGACTGTAATTGGTGGGGACAGCTAGTGGCCCTGCTGGGCTTCACACACGGTGTCCTCCC TAGGCCAGTGCCTCTGGAGTCAGAACTCTGGTGGTATTTCCCTCAATGAAGTGGAGTAAG CTCTCTCATTTTGAGATGGTATAATGGAAGCCACCAAGTGGCTTAGAGGATGCCCAGGTC CTTCCATGGAGCCACTGGGGTTCCGGTGCACATTAAAAAAAAAATCTAACCAGGACATTC AGGAATTGCTAGATTCTGGGAAATCAGTTCACCATGTTCAAAAGAGTCTTTTTTTTTTTT TTGAGACTCTATTGCCCAGGCTGGAGTGCAATGGCATGATCTCGGCTCACTGTAACCTCT GCCTCCCAGGTTCAAGCGATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCG TGCACCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTG GCCAGGCTGGTCTCGAACTCTCCTGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTG CTGAGATTACAGGTGTGAGCCACCCTGCCCAGCCGTCAAAAGAGTCTTAATATATATATC CAGATGGCATGTGTTTACTTTATGTTACTACATGCACTTGGCTGCATAAATGTGGTACAA GCATTCTGTCTTGAAGGGCAGGTGCTTCAGGATACCATATACAGCTCAGAAGTTTCTTCT TTAGGCATTAAATTTTAGCAAAGATATCTCATCTCTTCTTTTAAACCATTTTCTTTTTTT GTGGTTAGAAAAGTTATGTAGAAAAAAGTAAATGTGATTTACGCTCATTGTAGAAAAGCT ATAAAATGAATACAATTAAAGCTGTTATTTAATTAGCCAGTGAAAAACTATTAACAACTT GTCTATTACCTGTTAGTATTATTGTTGCATTAAAAATGCATATACTTTAATAAATGTATA TTGTATTGTATA OMIM ID 613609