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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-DMA (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3108 Official gene symbol HLA-DMA Full name major histocompatibility complex, class II, DM alpha Aliases ,D6S222E,DMA,HLADM,RING6, Gene summary HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 32920899 - 32916391  Map Viewer Gene orientation minus Gene size 4509 bp Gene sequence >HLA-DMA:complement(4360917..4365428):Length=4512 GATCTAAGGCCACCCTCTCGGGGAGGGAGTTGGGGAAGCTGGGTTGGCTGGGTTGGTAGC TCCTACCTACTGTGTGGCAAGAAGGTATGGGTCATGAACAGAACCAAGGAGCTGCGCTGC TACAGATGTTACCACTTCTGTGGCTGCTACCCCACTCCTGGGCCGTCCCTGAAGGTAAGA TGGTACTCCTATTTACTTCCATCCTGAACCTAGGGAGCCCACTCAGCTTTGTGAGGAAAA GCGCTGTGCTTTGTGAGTGGTGGGAAGTCTTATGAGGCAGTGGAAACAACAGGGGAGTGG GGAAAGACAGCTGCTATGTGTGGTTGGTAAACGATATCAGTGATGCTTTGCATGTTCCAT TTAAGACAATCTCTTGAAGCGGAGATTGTTCTCTCCATTTTACAAATGAAGAAAATGAGA CTCAGAGTTATTTGTGCAAGTTCACACCATTGGAAAGTGGTAGAGCTGGGATTTGAACAA AGTGAATGTTATTTTCACTCCTCCACTCAAGATTCTACTCTGCTTTCTATCATTAACTTA TCTTGTGATTCTTGAAAAGTGTCTTAGTTTCCTTCTCTGTAGAGGATGGGGCAGAATGGA AGAATAATCTGGAAGATCCCTCTTCCTCCAAATGTCTGTTTTTCTGGGTATTGGGTTAAA GGTTTCCTGCTGGCTGAGCGATTCCTGCCAAGAGCTTCAAAGAAGAGGGATTATTTTATG CAGTTATGGGGTCACTTCTCCCATTGCTGTCTTTGGGAGGCCTGGTAGGTTAAGGAACAG AAGACATTTTGAGAGACGCTTGGTGCCAATGAAGTGGCTGAAGAAATGTCTGGATACAGG TTTTCCAATTTACCATTTGTGTCTGGGGATAGTGGGAGGCAGTCCCATCTATGGCTTGGG GAGGCTGTAGCCATTCCTCCTCTTTCCCTTCTAAGAGTGAGAAACCCATCCATGGCCTTC TCTAGTCAATACAGTGGCCTGGTATGAATTAGACAAAGGAATCCCCTTTGGGAGGATACA GCCCTATGCCAGGATGTATGGCATGGTGAGCAGAATGCAGGCTTTCACTTGCTTCTTTGG CTAGGTGTCTTTGTGCAGCCCCCAAACACACAATGAACAGTGACTCTGAATCTGTCACTT TATTTTATATATATACATTTTTAAATTTTTTATTTGATTTAATTTATTTTTTTTGACACG GCATCTCGCTCTGTCACCCAGGCTAGAGTGCAGTGACGTGATCTCGGCTCCCTGCAACCC CTGCCTCTGGGGTTCAAGAGACTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGG CGCATGCCACCACACCCAGCTGATTTTTGTATTTTTAGTAGAGATGGGGTTTCATCATGT TTGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAG TGCTGGGATTACAAGCTTGAGCCACCGCGCCCGGCCTTTATATATATATTTTTTGAGACG GGCTCATTCTGTCACCTGGGCTGGAGTCCAGTGGCACAATCATGGCTCACTGCAGCCCCA ACTTCCTAGGCACAAGCAATCCTCCTGCCTCAGCCTCCAGAGTAGCTGAGACCACAGGTG TTTGCCACCACACCTGGCTAAGTTTTTGTATTTTTTGTAGAGACAGGGTCTCGCTGTGTT GCCCAGGTTGGTCTTGAACTCCTGGGCTCAAGCAATCTGCCTGCCTCAGCCTCCCAAAGT GCTGGGATTACAGGCATGAGCCACCATGCCTGGCCTGAATCTGTCACTTTAGAAAGTAGA ACTCTTTACTTTTGCCAACTGGCCTTTTTATAGGCAGGGGAAGCTTGGAGAGATGCCATA ATTTGTTCTTCACCCCCTTTGGGAGGGGGAGTCTAAATAACAGACACAGGAAAGGGTCTC ACCTCAGCCCACGCTCCTTAAGCAGGCCTTGCTTGTTTTTGTTGTTTTGTTTTGAGACAG AGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCTTAATCTTAGCTCCCGGCAACCTC TGCCTCCCTGGTTCAAGCAATTCTCCTCCCTCAGCCTCCCGAGTAGCTACAGGCGCATGC CAACATGCCCAGCTACTTTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATGCTGGCCA GGCTGGTCTCAAACTCCTGACCTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGA TTACAGGCATGAGCCACTGCGCCTAGCCCCACCTTGCTGTTTTTTAAGTTGGAGGAGAAG GCTCCCACCTCCCTGAACCTCACCCTGTGTCCTTTGCAGCTCCTACTCCAATGTGGCCAG ATGACCTGCAAAACCACACATTCCTGCACACAGTGTACTGCCAGGATGGGAGTCCCAGTG TGGGACTCTCTGAGGCCTACGACGAGGACCAGCTTTTCTTCTTCGACTTTTCCCAGAACA CTCGGGTGCCTCGCCTGCCCGAATTTGCTGACTGGGCTCAGGAACAGGGAGATGCTCCTG CCATTTTATTTGACAAAGAGTTCTGCGAGTGGATGATCCAGCAAATAGGGCCAAAACTTG ATGGGAAAATCCCGGTGTCCAGAGGTCAGGAGTTTTCTGGGGAGTGAAGGGAGGAGGGCT GCATTAACCTCATTGATCTGTACACTGAATAATTCCCCTTGATACCAGCTCCCCATCTCA AATACTTTCTGGTTCTCTTCATCACCTTAATTTTTCCACCAGCCTTGGTCTGCACCCTGT GTTCTTTTGGTGGGCCGAAGTACCTAGCATGTAGTAGGCATTCAGAACTATGTATTGAAT GTGATGAATTCAACAGGTACCAACTGATACCTACTGAATATTAACACTTGTGCTACTATG CCCAGCAAGATGGATGGGAAGAGTGGAAATATCTGATGACGTGACTATGTCTTAGTGAGA AGACAGTGCATGGTTAGACATCAATGTGAGCTCTAGACAGGAAGTGCTGAAGGAAGTCAT GGTGGAGGGGTCCAGAGTAGCCTGGATCTGGCTCTGCTTCTACGTCTAGCTGCAGTCCTT GCCTGGAAGAAGACCTCCCTTCAGAGCCCAGCTCCTCGCTCATCTCTGTCTCCCAAAGCC TGACCCACTGTGTTCTTCTCTGCCCTCCCCTCCATATGCCATGGCCCCTCCAAACACAGA GATACCATCTAAACTAGTCTCTTTTTCCCCCTACACTTCAATCCCCCCACCAGGGTTTCC TATCGCTGAAGTGTTCACGCTGAAGCCCCTGGAGTTTGGCAAGCCCAACACTTTGGTCTG TTTTGTCAGTAATCTCTTCCCACCCATGCTGACAGTGAACTGGCAGCATCATTCCGTCCC TGTGGAAGGATTTGGGCCTACTTTTGTCTCAGCTGTCGATGGACTCAGCTTCCAGGCCTT TTCTTACTTAAACTTCACACCAGAACCTTCTGACATTTTCTCCTGCATTGTGACTCACGA AATTGACCGCTACACAGCAATTGCCTATTGGGGTGAGGCTTTCTCCCTGGAATTCTGGTC CTTTTGGGGGCAAAAAGGGATAGATCCATGGGAGGAGGCTTCTTTCTCCACTGGTACCTT GTTTAGTCCATTCCTACCCTAAGCCCATCCCAGTCTCCCATGTCATCCCAGACACCCACG TCATTTCCCTGGGTGGGAGGCTCCCTAACTAGGTCCCCAGGCTGAGCCACTCATTTCCTC CAGTACCCCGGAACGCACTGCCCTCAGATCTGCTGGAGAATGTGCTGTGTGGCGTGGCCT TTGGCCTGGGTGTGCTGGGCATCATCGTGGGCATTGTTCTCATCATCTACTTCCGGAAGC CTTGCTCAGGTGGTATGTCATCTGGAGGGGGCGGGTGAGCCTGTGGGAGCCAGATACAGT GGTGCATGCGTGCATGTGTCAGGATTATTTTGTGGCATGGGGGGACATATAGCGATCCTC AGGCCCTTGGGTGTGGGGGCCTGTATCCAGCACCATGGGGGCACATCTTCCCAGTTGGGG ACCCAGTTACACACACACAGTTATGGGTCACAAGAATTGCTTTGAGTGAAAAAAGGAATC ATGGGGTGCTGTAGGAAGGGTGCTTGGAGATGATTTGGGAACAAGGAGAGATCAACTTCT GCAGGGTGTGGTGCAGGCAGGGCGAGCAAGGCCTTTGTGGGGGAGGAGGAGGAGGAGAAG GAGGAGGAGGATGGATCCCCTGATGCCTTTCCTCCATCCCTGTCTCTCCCCCAGACTGAT TCTTCCAGACCAGAGTTTGATGCCAGCAGCTTCGGCCATCCAAACAGAGGATGCTCAGAT TTCTCACATCCTGCCCAGGATCTCCTCTTAGGGTAGAAGAAGTCTCTGGGACATCCCTGG GGTGTGTGTGTAGATTTCCCACCTGGGGACTCTGCTGTCCCTGGGCTTGCATCCCAGGGA TCCCAGAGTGGCCTGCCTATCACAACCACATCCCTTCCCCCCACAAGGCAATAAATCTCA TTTCTTTATATC OMIM ID 142855