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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-DMB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3109 Official gene symbol HLA-DMB Full name major histocompatibility complex, class II, DM beta Aliases ,D6S221E,RING7, Gene summary HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 32908847 - 32902406  Map Viewer Gene orientation minus Gene size 6442 bp Gene sequence >HLA-DMB:complement(4346930..4353371):Length=6442 ATTTGTCCCTGCCTACCTAGCCAATCTGTCCCTGTTTGGGACACTGGACTCCCGTGAGCT GGAAGGAACAGATTTAATATCTAGGGGCTGGGTATTCCCACATCACTCATTTGGGGGGTC AAGGGACCCGGGCAATATAGTATTCTGCTCAGTGTCTGGAGATCATCTACCCAGGCTGGG GCTTCTGGGACAGGCGAGGACCCACGGACCCTGGAAGAGCTGGTCCAGGGGACTGAACTC CCGGCATCTTTACAGAGCAGAGCATGATCACATTCCTGCCGCTGCTGCTGGGGCTCAGCC TGGGCTGCACAGGAGCAGGTAAGGACACTTCTTCTGGGGACTCTCCCTTCCCCTGCTCCT GTTTCAGGGTAAGGGTGTTCCGTTTTGTAATTGCATTTGACACCCCAGATAGTTTGTCTC CCTGGTATACATTCCTATAGCACTTTGTACTTTGTAGCAATTTTAATGTAATTAATCTGT ATAATTATCTGTGCAGTGTATATTCCCTGCTGGAATATAGGCAAGGACAATGTTCATCTT ATTTATTGCTGCCTCCTCAGCTCCTAGCACAGTGCCTTGCATGCAGCAAGTGCTTCATAA ATATGTGCGAAGTGAATATTTAATATTTCCAGCACAATACAAGGCTGACTCTTTCTCTTG ACCCTTTTTCTCTCTCAATAATTTGCCTTACTGAAGGTCTGTGTTCTGGGCAAATTGTCA TGTTTAAACATGCAAATAATCTCGGGGGGCTACTCCTATCCCTGTGCTTAGTCTTGCATA AAGAGGAGACTGGATCTAAAAACTTATCTACTACTTCTACTGACTCCCTCAAATCAGACT TTCAGAAACTTCAGTGTATGAGCTTGGTCAGTAGATGTTCCCTGAGCAGGAAATCTGTGC CAGACTAGCTGGATGTCACCAAGGCTTAGGTTCTGAGCTGAATATAGGAAAAATCAACTT TTTTTCTTCTATATGCTCACACTCAACACTTCTTTGACCAACTGTGTGAGGTTTTTTTTT TTTTTTTACTCATACCAACCAATTCTCCTATATTAGCTGGATATCCTATAATTCAATTCC ATTGTGACATTAACTAGAGTTAACATAGACACCAAAGGTTAAAGACTCAGTCCCATAAGA CTGCCTCCATTTCAGACACCAATCACAAGTAGTAGGTTCCCAAATTACCCACATCTTCTG TCCAACTTGCCTACAAATCAGAGGTTCCCATGACCCCCTCCTTGGGGTTGGTAATTTGCT AAAGTGGCTTATGGAACTCAGGAAAAGTTTACTTATTATTGTAGATTTTTTACAAAGGAT ATTTTAATTGATAATAATAATTATAAATATTCATGGGGTGGATAATGATGTTTTAGTACA TGTAATGTACAGTGATCAGATCAGATCATCATCTCATTTATCATTTCTTTGTGTTGGAAA CATTCCATATCCTTCTTCTAGCGATTTGAAATGATATAAAGTATTATTGTTAATGACAGT CATCCCACAGTGGTATAGAACACTAGATCATAATTTTGCATCCTTTAACAAAGGATATTT TAAAGCATACAAAGGAACATCCAGATGAAGAGATACCAGATCTGGAAGGGTCCCAATCAC AGGAGCTCTGTCCCCACAGAATTGGGGTACTTCACCTCCTGGCATGTGGATGTGTTTACC AACTGAGAAGTTCTCTGAACTCCATAGTTCCGGGATTTTTATGGAGGCTTCATCATGTAG GCATGACTGATTATTAACTCAATCTCCAGCCCCTTCCCCTTCAGGGAGTATGGGGGATGG GACTAAAAGTTCCAGACTTCTAATCATGACTTGGTCTTTCTGGTGACCAGCCCCTCCTGC AGGAGCCCACCAAGAGTACCTCATTAGAACAAAAGACACTCCTGTTATCTAGGAAATTCT AAGCGATTAGGCACTCTATGTCAGGAACCAGGGTCAAAGACAAAGCTCTGTGCAGAGCTC CTAAATATACGTCTGTATGTTTTATATATTTATTATTTGTGTATATTTATTATTTATATA TTTATTTATTTATTGCCAGGCCAGTAGAAGACATTGACCTGTTCTCCCTTCCCTGGCTCC TCTAGGTGGCTTCGTGGCCCATGTGGAAAGCACCTGTCTGTTGGATGATGCTGGGACTCC AAAGGATTTCACATACTGCATCTCCTTCAACAAGGATCTGCTGACCTGCTGGGATCCAGA GGAGAATAAGATGGCCCCTTGCGAATTTGGGGTGCTGAATAGCTTGGCGAATGTCCTCTC ACAGCACCTCAACCAAAAAGACACCCTGATGCAGCGCTTGCGCAATGGGCTTCAGAATTG TGCCACACACACCCAGCCCTTCTGGGGATCACTGACCAACAGGACACGTGAGGAGAGAGG GGTGCAGAGGGGCTACCAGGAAGTGCAGTTAGGAGGGCAGGCCAGGGAGGATCCCACAGT GGCCCAGGGGTTTGAGATTTGAGCAGCAAATAAGAGAAAATGTGTGGATCTGAAATGTAG AAAGACGGAGGATTGAACCTCAAGGGGAACAAGGTGGCTGACGTGAGTGGAACAGGAGTA AAGAAGGGGAGGTGAGGCTTGAACCGCGAGGTGCCATGTGGGGAGCTTATGCAGAGGCTG GGGCATCTCAGGATGCATACCCAAGATGTTCTTGCCTTGTTATCCCAGATTTTGATGTTC CAGATCTGATGTGGGCCCAGGCATGGGAATATTTGGAATCCCAGGGGATTCTGACACATG CTTTTTCTCACCCTTAAACTCTTGCATTGACAATGGCTTGAAGTTTGTGAAAGTAAACTT GAAGATCTCCACAGTACAGAACAGTGTGTCTCAAGGGTGGTTTCTGAACCACCTTTCTCA GAATTGCCTGGAGGAGGTGCTTGTTAAAGATGCAAGCCCCTTAGTACCACTCCAGATCTG TTGAAAGAAAGTATCTGGGGATACAGCCTAGGAAATCTGCATTTTAACATAATTCCTTGG ATTTTTATTTAAGATTGTGTTTGAAAAATGTCAAGATAGAGGCAAGCAAGAGGATCACCT AGGAGAGTAAATTAGTAAAAGATGGCAGTATTAGCAATCTCATTAGTTTGACTACATTCA TTCCAAATTTAAGAGTGAGTCCTAAGTTAGGCTTGTTTCCTTGAACTATGTGAGGAGAAA AAGCTTTAACTAGCAAAAGAACGTATTAAACAAGATTTGGAGAAAAATTCCTTTTCCACC TTAAAAAAACCCAATGTACAACTCTGGATTACTCTTAGCTTCCTTATTTCAAATACTTTC CAGTTTATGTACTTGAAATAAATACAACAACTTCTAGAACAGCTTGCAGTTCAGATCTGG CTTTTACTAATTGTAATCAAACATAATTCTGGAGGAGGAAAGAAAGAAAGGGGCAATGAA GGAATGGGAGAGAAGAAAGAGTAATGCAGGAATACATTCTAACGGTTCCCCTTCAAGGGG CAGCATGGCAGAGGGGGCTGGGGTGGAAAGTGGGTTGCAAAATCTACGAAGAGTTGCGAT AGGGAAGAAACCAGGTTGAGGAAGCAGCCAGAATGTCACCCTCCTTCCTAAACATGTTTT TTTCTCCTATGCAGGGCCACCATCTGTGCAAGTAGCCAAAACCACTCCTTTTAACACGAG GGAGCCTGTGATGCTGGCCTGCTATGTGTGGGGCTTCTATCCAGCAGAAGTGACTATCAC GTGGAGGAAGAACGGGAAGCTTGTCATGCCTCACAGCAGTGCGCACAAGACTGCCCAGCC CAATGGAGACTGGACATACCAGACCCTCTCCCATTTAGCCTTAACCCCCTCTTACGGGGA CACTTACACCTGTGTGGTAGAGCACACTGGGGCTCCTGAGCCCATCCTTCGGGACTGGAG TAAGTGTATGGCAGATGGATGGAATTAGGGTCAAAGCAGAGAAAATGAGATGTGGATCGA TACATGGTACATGGTAGACAGCGAAGTGCTGAAAATGGGGACTGAGTCTGGAGGAACTTA CGGGGGGCTTAGGACCAGAATGGGGAAATGGGATAAAGAAATGGAAATATTTAGGTTGGT GCAAAAGTAATTGCAGTTTTTGCCATTACTTTCAGTGGCAAAAACCGCAATTACTTTTGC ACCAGTTTAATATTTAGTCTGTGCTATTGCTGCTCTGGTGGTGTGGCTGATGTTGCTGCG TCTATGTTTGAGGGTGAGAGGGGAGCGTGCTTGCTTTGAAATGAGGCTGTAAATTTGGCA ATCATATTTTCAGAACCCCAAATTGTAATACACTATTCTAGCCTCCTTAGATTTCAACTA TTCTGGTGCCAGAAGCAGATGGGAGCTGAAGGAATGATGAAGGTTGAAGAAGGGGGGCTT TTCTTGGTGTGGGGCAGTACTGCATTTGGCCTGCTCTACCAAGCATACGGGAGTAGTAAA GCCACGGCTGGCAGACCATTTGGCATGCATGCTCAGGGGCCAGTGGATAAAGAATTACTT ACAGTTCAAACACTGTTTGAACTCAGTGTCGGGAGTAGTTAAAGGTATCGTGAGAAGTTG CACACAGCTTTGGGGACTCTTGGAAAAGAAAGAGGAAGAAATGAGGAAGAGGAAGGGTGT CTACAAAGGGCCAGAGAACAGGATCTCAGATCAGCTGCTGTAACCAGGTTTCCCCTTGTG GGAAGTGTTGTTTCTTGCTGGGCAGTTGGGAAGGGAATGGAGAACAGAGAAGAGAGTGGA AATCACATGCTCACTTGAACTTTCCTGGGGAACGTCTCCTCACAGCGTGCACAAGAGCCT CCCTTTGGAAATGGAGTGTTCATTTTATCATGGGAAAAGAATCTGAGTGGGACATGATTC AGAACAGGACCGGCCCAAGGAAGTGCAGGGGCTGTGGAGTGGGATGGAGACAAGCTCTGA AAGGACACATGGGAGATCTAGATGTAGAAGGTACACAAGTAGTAGGATAACTCACAGGAT GGATCCACTGGAGGTTAAGACATGTGGTAAGACAGTGTAATAGGAAGCTGCTCAGTTGGA GAAAGTAAGGAAGCAAACATTGTTACCGTGGGGGCAATGGAGAGGACAGTGAGGAGCCCT TTATCCTGATAAGGGTGGCTTTGGGGTAAAGGAAGGAAAGAGGATGCCTTGAGAGGCCCC ACTGTATTAGAGAGGACCTGGAAGCCAGGATGCTAATTCTGGGGAGATGGGTTCCCCAGG CTTACTCTAGGAGTAGAGGTCCATGGGACGAGGGTTTGATTTGAGAAAGATCATTTTCTT GGGAGTGGGTGGTGTGAGCTAGACCCTTGGAGCTGGGATAAAGGACCTTTTAACCCACTG AGAGGTGGCTGCAATAAATGGAATTGCCCTGGGGGTGAGCAACAGAAACTGGGTCAAGTA AGTTTCTATTTTTTGCAGCACCTGGGCTGTCCCCCATGCAGACCCTGAAGGTTTCTGTGT CTGCAGTGACTCTGGGCCTGGGCCTCATCATCTTCTCTCTTGGTGTGATCAGCTGGCGGA GAGCTGGCCACTCTAGTGAGTGACTCGCTGAACTCCCATCCCCACTCTTGGTCCCACTCT CTGCTTACTTTCTGTTTGTGATTAACTCTCTCCTTCCTACTGCATTTGCTATGAATACTG CTAGATATTTTCATCCACAAAGACTGGTATAATCAAGTATCTTCCTCTCTTAGGTTACAC TCCTCTTCCTGGGTCCAATTATTCAGAAGGTAACATCTCTGTTGGTCTGTTTCCCTACTT GCCCTTTGGTAGGGGTGCGGGTTAGAGGGGTCAGTGTTGGGTTCAACTAATCTTGATTAT TATATGGGTGAGCTTCCATGAGGATCTAGGCAAGGGCATGATTTAAGCTGCCATTGCTAG GATTAAGAGCAGGAAGGAGCATCCTCCTCTTCTACCAAGTGGGATGTCTGTGGAGAGGAG GCTGAAGGTGCTTCCTTTGTATTAGTTGTTGGTGCCCTGGAGTTTTCAGTATCACTGTAT TAAGGCATGGGATGGTTACAGTGACAAACGATGGGGGCAAGTTGGGTTGAAGCCTCATTA TCTCCCTTTTATTTATTCTGTAGGATGGCACATTTCCTAGAGGCAGAATCCTACAACTTC CACTCCAAGTGAGAAGGAGATTCAAACTCAATGATGCTACCATGCCTCTCCAATATCTTC AACCCCCTGACATTATCTTGGATCCTATGGTTTCTCCATCCAATTCTTTGAATTTCCCAG TCTCCCCTATGTAAAACTTAGCAATTTGGGGGACCTCATTCCTGGGACTATGCTGTAACC AAATTATTGTCCAAGGCTATATTTCTGGGATGAATATAATCTGAGGAAGGGAGTTAAAGA CCCTCCTGGGGCTCTCAGTGTGCCATAGAGGACAGCAACTGGTGATTGTTTCAGAGAAAT AAACTTTGGTGGAAATATTGTT OMIM ID 142856