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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HLA-DOB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3112 Official gene symbol HLA-DOB Full name major histocompatibility complex, class II, DO beta Aliases ,DOB, Gene summary HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 32784825 - 32780540  Map Viewer Gene orientation minus Gene size 4286 bp Gene sequence >HLA-DOB:complement(4225070..4229355):Length=4286 GATTTATACTCTTAATGGGTACTTTCTGACTGAATTTTATGAGCTCATTCTGAAGAGGCT GACGATTTTACTATCTCATTTTTTTCCTTTCTCCAGAATGGGTTCTGGGTGGGTCCCCTG GGTGGTGGCTCTGCTAGTGAATCTGACCCGACTGGATTCCTCCATGACTCAAGGCACAGA CTCTCCAGGTAAGAACAGAGCAATTGTTTTTTTCCAGTGTGTATGCAAGAATTGGCATGG GGGAGTGATGCCTTTCTTTGTAAGTCCAGGCCACAGACCAGACTGGAAGTGGCTTTTGGT TTCAAAGAACAGTGTTCTTCCCTTTGGCAGAAAGGTACGCCTTGCCTCTTTACATGGGAT GGACTTCATATACCAGAGCCACCTATTCAAGGGGTAGGGAGGCAGGAAGAGGGAAACATT GTGTCTTGTTTAGGATCCTTATTGTGTGTATCAACCTCAGTCAGTGCCTGGGCGTGTTGA AGGCCTTGGCTTGGGTTCGAGCCTGCTGGGAGAAACAACCTGCAGTAGGCTGGGTCACAG AGGCAATCTGTGATTTTTTGGTCAGGACACGGAAACAAATCTCAGTTGGGGTATATGTGG ACAAATGAAACTGGAAACAAAGGTTGCTCCTTCTGTCATTTATTAAGCCACTATTATATT GTCAGAATTGTACTAAACAGTTTTGAGAAGTAAGAGAAGTTGAATAGAATACATTGTCCT TGTCCTCCGGCTACCAGGTACAAGTTACTTGTCACTGTTATTTTTCTAGCACAGGTGACA GAATATGCAGCCATGAAGCAATGTGAGATGAAAGCACATATTAATGAGCAGAAACAGGAT GTAATGTGCTAAGAACAGAATCCCCTTTGCATGTTAGTTTCATTAAATACAAAAGAGGAA CAAACCTGGCCAGGAGAGATCATTATTCTCAGAGAATAGAAACCGCCCTGAGTTTATAAT GTCCATTAAACAATACAACTGAAAAAAAAATCAGCACAGATGTTAAATGATGATGAAAAA TTCAGATTTCCCCCCTGGTTTAGACTACTAGAGGAAATAGAGAAGAGTATACATGCTGAG AAATTACAGGCTGGAACTTCATCTGAAATTAGCTACTGAGTGAGGGATAAGTGGGGTTCA CCCAGGAAGGTCATTCTTATGGCTCAGTTCAGAGTTGGAGGAGGCTTCTGAACTTAGAAA GGAAAGTAAATTACAACCCAACATTAATAGCAATTATCTTTCAAGTCTTGACTTAGATGC AATGTCTTCAGGACGTCCTTCCTGACTTACCTACATTATTAACTCCATTTGAATTTCCTT TTTATTGTAGTTGTTGTTCTTAAGTGCATAGGATTGGTTTAATTTTACCCAATGAGTTCA CAGCACATTGTAATTATTGGCAGTAGTGCAAGACTCTCTCGTCTCTTCTCTTGCCTCCGT TCTCATTCTCTCCCCTCCCTAGAGAATCCATTCTAAACGTGTCTGGTAAGTCTCTAAGTA TGAGAGTGGCTTTTAGAAATATGTAGCATTATTGCTCTTTATGTGTTTTTAAAATTTAAT AAATGTCATTCTCTGTTGAATCCCATTCTGTTTCTTTTCTCACTTGACACTGTGCTTTTT GAGCATACTGAGGTCAAAGGCCTCCTCTTAGATCCATGTGGTCTGACGTAATTTACCAGG CATGGGTTTTCCCAGAGGAGGGGGCTGGTTCATGGTTTTGGTTTTGGTTTTCCAGAAGAC TTTGTGATTCAGGCAAAGGCTGACTGTTACTTCACCAACGGGACAGAAAAGGTGCAGTTT GTGGTCAGATTCATCTTTAACTTGGAGGAGTATGTACGTTTCGACAGTGATGTGGGGATG TTTGTGGCATTGACCAAGCTGGGGCAGCCAGATGCTGAGCAGTGGAACAGCCGGCTGGAT CTCTTGGAGAGGAGCAGACAGGCCGTGGATGGGGTCTGTAGACACAACTACAGGCTGGGC GCACCCTTCACTGTGGGGAGAAAAGGTGAGCTGGAAGCTGAGGTCTGGCGGGGCTCAGGA ATGTCCCCCATGTGAACCTGGCCATGGCTCTTCTTTCTTACAAGCAATTTTCTGCTTTAG GATAAATGGTTGTCTGTGTAGATGTTCTGGCCCCAGCTGTGATATATTATCCTCACAAGT CAGCCACTGTGATCTTGGTCTCAGACCCCCAAGGTTCTCAGGGACTTCGAGGGCTATTGT GCCCTCAAAGAGAAGCAGTAATTGTGGGAGTACCTCAGAAAGTCTAAATCCTCCTGACAG GCATTGACATACCCTGTTACTGATCTTGGGGGCTGAGACTTGCCTATACTTTGTGTTCAC TTGGGTGATCTGGGAAAGAGATTAGACATAGTGATAGTCCCTAAAGAATCTCCTGTCCCA GCTTGGTGGTTTTCTTTCACGGTGTCTCATTTTTCCTCCCTTCCTAGTGCAACCAGAGGT GACAGTGTACCCAGAGAGGACCCCACTCCTGCACCAGCATAATCTGCTGCACTGCTCTGT GACAGGCTTCTATCCAGGGGATATCAAGATCAAGTGGTTCCTGAATGGGCAGGAGGAGAG AGCTGGGGTCATGTCCACTGGCCCTATCAGGAATGGAGACTGGACCTTTCAGACTGTGGT GATGCTAGAAATGACTCCTGAACTTGGACATGTCTACACCTGCCTTGTCGATCACTCCAG CCTGCTGAGCCCTGTTTCTGTGGAGTGGAGTGAGAATTAGTTTCTAGTACTCTCTGGGCC TGACTCAGGACTATACTGACTCAATACAGAGCCTGTGTCACTTCTGCGTTTATCTTGGTC ACAACATGAATTATTCTTTCCCTTGATCTGGGACAGTCACAGAAACCAGAGTCCTTGGGT TAGGGTGGGAGAAAACATGGCAGATATCTATCCTCATATCTTCCAAGAAATGAGGAGATC TAATCACCTCATTATGTGCTTCCAACCCTATGAACTGGTGTCCTCTAATTCTTTGGTCTT AGTATTTAGGAGGCATTCTTATGGGCTGTGAGAATCTGTAACCGATGGGGGGTAACTCCA TGGGTGCCAACTTTGGTTTCGAAGAACCTTTTCTAAATTTATTTATTTTTCTCTAGCTAG CATTGGATTTGGTGTCTAGTACAGATTCTGGGATTCCAAGAAAGTGCTTTAAATATTGGG ATATTTTTACTAATTTAAAGACCTGTTTCCCATAGGAGCTCAGTCTGAATATTCTTGGAG AAAGATGCTGAGTGGCATTGCAGCCTTCCTACTTGGGCTAATCTTCCTTCTGGTGGGAAT CGTCATCCAGCTAAGGGCTCAGAAAGGTAATGAGCCTGTGAGGAGTGCCCTGCCACCTGT CCCAGACCTTCCCCACTCCCACCTTCCCTAACGTCAATGATCTGAGGCAAGGAAAGCTGA TTGTGCCTCTCAGGGATCACCGGGATAATTTTTTTCTGAAGCTAGAAATGGGATAAGCAG AGAGAGTGCTGACCTTGCCAGCCATTTGTTCTTCCCTCGGGATAATCATATTGGGTCCTA ATTGGGGCAATCCATTCTTTTCTCGATTTCTTTCCAGGATATGTGAGGACGCAGATGTCT GGTAATGAGGTAATGTCTCTTTTTCCTTGTCTTTGAGTGGCAGATCATTCTCCCGGTTCT TTGGCCAGAGGGAGATGACATGGGGGTAGGGAGGAGTAAGGTTGCTGCTGTCTGGATGGG ACTGTCCCCTGAGTCTCTGGAACGGCTGTGGGGGGTGGTGAGGCTGCCTCCTGAGACCTT CATCACTGTGCCTCCAGGTCTCAAGAGCTGTTCTGCTCCCTCAGTCATGCTAAGGTCCTC ACTGAAGCTTCTCTCTCTGGAGCCTGAAGTAGTGATGAGTAGTCTGGGCCCTGGGTGAGG TAAAGGACATTCATGAGGTCAATGTTCTGGGAATAACTCTCTTCCCTGATCCTTGGAGGA GCCCGAACTGATTCTGGAGCTCTGTGTTCTGAGATCATGCATCTCCCACCCATCTGCCCT TCTCCCTTCTACGTGTACATCATTAATCCCCATTGCCAAGGGCATTGTCCAGAAACTCCC CTGAGACCTTACTCCTTCCAGTCCCAAATCATTTACTTTTCTGTGGTCCAGCCCTACTCC TATAAGTCATGATCTCCAAAGCTTTCTGTCTTCCAACTGCAGTCTCCACAGTCTTCAGAA GACAAATGCTCAGGTAGTCACTGTTTCCTTTTCACTGTTTTTAAAAACCTTTTATTGTCA AATAAAATGGAGATACAAAAAATGTA OMIM ID 600629