Entrez gene ID | | 3273 |
Official gene symbol | | HRG |
Full name | | histidine-rich glycoprotein |
Aliases | | ,DKFZp779H1622,HPRG,HRGP, |
Gene summary | | This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3q27 |
Gene position | | 186383798 - 186396023 Map Viewer |
Gene orientation | | plus |
Gene size | | 12226 bp |
Gene sequence |
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OMIM ID | | 142640 |