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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HUS1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3364
Official gene symbolHUS1
Full nameHUS1 checkpoint homolog (S. pombe)
Aliases,-,
Gene summaryThe protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq]
LocationChromosome: 7   Locus: 7p13-p12
Gene position48019246 - 48003783  Map Viewer
Gene orientationminus
Gene size15464 bp
Gene sequence