Entrez gene ID | | 3364 |
Official gene symbol | | HUS1 |
Full name | | HUS1 checkpoint homolog (S. pombe) |
Aliases | | ,-, |
Gene summary | | The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7p13-p12 |
Gene position | | 48019246 - 48003783 Map Viewer |
Gene orientation | | minus |
Gene size | | 15464 bp |
Gene sequence |
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