Entrez gene ID | | 3400 |
Official gene symbol | | ID4 |
Full name | | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
Aliases | | ,IDB4,bHLHb27, |
Gene summary | | Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995 [PubMed 7665172]).[supplied by OMIM] |
Location | | Chromosome: 6 Locus: 6p22-p21 |
Gene position | | 19837617 - 19840915 Map Viewer |
Gene orientation | | plus |
Gene size | | 3299 bp |
Gene sequence |
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OMIM ID | | 600581 |
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