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Gene information for IDH3A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3419
Official gene symbolIDH3A
Full nameisocitrate dehydrogenase 3 (NAD+) alpha
Aliases,-,
Gene summaryIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq]
LocationChromosome: 15   Locus: 15q25.1-q25.2
Gene position78441719 - 78462884  Map Viewer
Gene orientationplus
Gene size21166 bp
Gene sequence