Entrez gene ID | | 3419 |
Official gene symbol | | IDH3A |
Full name | | isocitrate dehydrogenase 3 (NAD+) alpha |
Aliases | | ,-, |
Gene summary | | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q25.1-q25.2 |
Gene position | | 78441719 - 78462884 Map Viewer |
Gene orientation | | plus |
Gene size | | 21166 bp |
Gene sequence |
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