Entrez gene ID | | 3420 |
Official gene symbol | | IDH3B |
Full name | | isocitrate dehydrogenase 3 (NAD+) beta |
Aliases | | ,FLJ11043,H-IDHB,MGC903,RP46, |
Gene summary | | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 20 Locus: 20p13 |
Gene position | | 2644843 - 2639041 Map Viewer |
Gene orientation | | minus |
Gene size | | 5803 bp |
Gene sequence |
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OMIM ID | | 604526 |
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