Entrez gene ID | | 3421 |
Official gene symbol | | IDH3G |
Full name | | isocitrate dehydrogenase 3 (NAD+) gamma |
Aliases | | ,H-IDHG, |
Gene summary | | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xq28 |
Gene position | | 153059967 - 153051221 Map Viewer |
Gene orientation | | minus |
Gene size | | 8747 bp |
Gene sequence |
| |
OMIM ID | | 300089 |
|