Entrez gene ID | | 3423 |
Official gene symbol | | IDS |
Full name | | iduronate 2-sulfatase |
Aliases | | ,MPS2,SIDS, |
Gene summary | | Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xq28 |
Gene position | | 148586884 - 148560295 Map Viewer |
Gene orientation | | minus |
Gene size | | 26590 bp |
Gene sequence |
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OMIM ID | | 300823 |
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