Entrez gene ID | | 3480 |
Official gene symbol | | IGF1R |
Full name | | insulin-like growth factor 1 receptor |
Aliases | | ,CD221,IGFIR,IGFR,JTK13,MGC142170,MGC142172,MGC18216, |
Gene summary | | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q26.3 |
Gene position | | 99192761 - 99507759 Map Viewer |
Gene orientation | | plus |
Gene size | | 314999 bp |
Gene sequence |
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OMIM ID | | 147370 |