Entrez gene ID | | 3565 |
Official gene symbol | | IL4 |
Full name | | interleukin 4 |
Aliases | | ,BCGF-1,BCGF1,BSF1,IL-4,MGC79402, |
Gene summary | | The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q31.1 |
Gene position | | 132009373 - 132018368 Map Viewer |
Gene orientation | | plus |
Gene size | | 8996 bp |
Gene sequence |
| |
OMIM ID | | 147780 |
|