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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL6ST (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3572
Official gene symbolIL6ST
Full nameinterleukin 6 signal transducer (gp130, oncostatin M receptor)
Aliases,CD130,CDw130,GP130,GP130-RAPS,IL6R-beta,
Gene summaryThe protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q11
Gene position55290821 - 55230923  Map Viewer
Gene orientationminus
Gene size59899 bp
Gene sequence
OMIM ID600694