Entrez gene ID | | 3572 |
Official gene symbol | | IL6ST |
Full name | | interleukin 6 signal transducer (gp130, oncostatin M receptor) |
Aliases | | ,CD130,CDw130,GP130,GP130-RAPS,IL6R-beta, |
Gene summary | | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q11 |
Gene position | | 55290821 - 55230923 Map Viewer |
Gene orientation | | minus |
Gene size | | 59899 bp |
Gene sequence |
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OMIM ID | | 600694 |
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