Entrez gene ID | | 3587 |
Official gene symbol | | IL10RA |
Full name | | interleukin 10 receptor, alpha |
Aliases | | ,CDW210A,HIL-10R,IL-10R1,IL10R, |
Gene summary | | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q23 |
Gene position | | 117857106 - 117872198 Map Viewer |
Gene orientation | | plus |
Gene size | | 15093 bp |
Gene sequence |
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OMIM ID | | 146933 |