Entrez gene ID | | 3595 |
Official gene symbol | | IL12RB2 |
Full name | | interleukin 12 receptor, beta 2 |
Aliases | | ,-, |
Gene summary | | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p31.3-p31.2 |
Gene position | | 67773047 - 67862583 Map Viewer |
Gene orientation | | plus |
Gene size | | 89537 bp |
Gene sequence |
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OMIM ID | | 601642 |
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