Entrez gene ID | | 3596 |
Official gene symbol | | IL13 |
Full name | | interleukin 13 |
Aliases | | ,ALRH,BHR1,IL-13,MGC116786,MGC116788,MGC116789,P600, |
Gene summary | | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q31 |
Gene position | | 131993865 - 131996801 Map Viewer |
Gene orientation | | plus |
Gene size | | 2937 bp |
Gene sequence |
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OMIM ID | | 147683 |
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