Entrez gene ID | | 3606 |
Official gene symbol | | IL18 |
Full name | | interleukin 18 (interferon-gamma-inducing factor) |
Aliases | | ,IGIF,IL-18,IL-1g,IL1F4,MGC12320, |
Gene summary | | The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q22.2-q22.3 |
Gene position | | 112034840 - 112013976 Map Viewer |
Gene orientation | | minus |
Gene size | | 20865 bp |
Gene sequence |
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OMIM ID | | 600953 |