Entrez gene ID | | 3615 |
Official gene symbol | | IMPDH2 |
Full name | | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
Aliases | | ,IMPD2,IMPDH-II, |
Gene summary | | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p21.2 |
Gene position | | 49066875 - 49061758 Map Viewer |
Gene orientation | | minus |
Gene size | | 5118 bp |
Gene sequence |
| |
OMIM ID | | 146691 |
|