Entrez gene ID | | 3682 |
Official gene symbol | | ITGAE |
Full name | | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | | ,CD103,HUMINAE,MGC141996, |
Gene summary | | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17p13 |
Gene position | | 3704537 - 3617919 Map Viewer |
Gene orientation | | minus |
Gene size | | 86619 bp |
Gene sequence |
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OMIM ID | | 604682 |
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