Entrez gene ID | | 3684 |
Official gene symbol | | ITGAM |
Full name | | integrin, alpha M (complement component 3 receptor 3 subunit) |
Aliases | | ,CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6, |
Gene summary | | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p11.2 |
Gene position | | 31271288 - 31344213 Map Viewer |
Gene orientation | | plus |
Gene size | | 72926 bp |
Gene sequence |
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OMIM ID | | 120980 |
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