Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ITGAV (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3685
Official gene symbolITGAV
Full nameintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Aliases,CD51,DKFZp686A08142,MSK8,VNRA,
Gene summaryITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q31-q32
Gene position187454790 - 187545628  Map Viewer
Gene orientationplus
Gene size90839 bp
Gene sequence
OMIM ID193210