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Gene information for ITGB2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3689
Official gene symbolITGB2
Full nameintegrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Aliases,CD18,LAD,LCAMB,LFA-1,MAC-1,MF17,MFI7,
Gene summaryThe product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
LocationChromosome: 21   Locus: 21q22.3
Gene position46348753 - 46305868  Map Viewer
Gene orientationminus
Gene size42886 bp
Gene sequence
OMIM ID600065