Entrez gene ID | | 3689 |
Official gene symbol | | ITGB2 |
Full name | | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
Aliases | | ,CD18,LAD,LCAMB,LFA-1,MAC-1,MF17,MFI7, |
Gene summary | | The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] |
Location | | Chromosome: 21 Locus: 21q22.3 |
Gene position | | 46348753 - 46305868 Map Viewer |
Gene orientation | | minus |
Gene size | | 42886 bp |
Gene sequence |
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OMIM ID | | 600065 |
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