Entrez gene ID | | 3706 |
Official gene symbol | | ITPKA |
Full name | | inositol 1,4,5-trisphosphate 3-kinase A |
Aliases | | ,IP3-3KA,IP3KA, |
Gene summary | | Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q14-q21 |
Gene position | | 41786122 - 41795747 Map Viewer |
Gene orientation | | plus |
Gene size | | 9626 bp |
Gene sequence |
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OMIM ID | | 147521 |
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