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Gene information for KDR (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3791
Official gene symbolKDR
Full namekinase insert domain receptor (a type III receptor tyrosine kinase)
Aliases,CD309,FLK1,VEGFR,VEGFR2,
Gene summaryVascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q11-q12
Gene position55991762 - 55944426  Map Viewer
Gene orientationminus
Gene size47337 bp
Gene sequence
OMIM ID191306