Entrez gene ID | | 3821 |
Official gene symbol | | KLRC1 |
Full name | | killer cell lectin-like receptor subfamily C, member 1 |
Aliases | | ,CD159A,MGC13374,MGC59791,NKG2,NKG2A, |
Gene summary | | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12p13 |
Gene position | | 10607215 - 10598627 Map Viewer |
Gene orientation | | minus |
Gene size | | 8589 bp |
Gene sequence |
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OMIM ID | | 161555 |
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