Entrez gene ID | | 3856 |
Official gene symbol | | KRT8 |
Full name | | keratin 8 |
Aliases | | ,CARD2,CK8,CYK8,K2C8,K8,KO, |
Gene summary | | This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q13 |
Gene position | | 53298868 - 53290971 Map Viewer |
Gene orientation | | minus |
Gene size | | 7898 bp |
Gene sequence |
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OMIM ID | | 148060 |
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