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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LRP6 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4040
Official gene symbolLRP6
Full namelow density lipoprotein receptor-related protein 6
Aliases,ADCAD2,FLJ90062,FLJ90421,
Gene summaryThis gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
LocationChromosome: 12   Locus: 12p13.3-p11.2
Gene position12419811 - 12268959  Map Viewer
Gene orientationminus
Gene size150853 bp
Gene sequence
OMIM ID603507