Entrez gene ID | | 4050 |
Official gene symbol | | LTB |
Full name | | lymphotoxin beta (TNF superfamily, member 3) |
Aliases | | ,TNFC,TNFSF3,p33, |
Gene summary | | Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6p21.3 |
Gene position | | 31550202 - 31548335 Map Viewer |
Gene orientation | | minus |
Gene size | | 1868 bp |
Gene sequence |
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OMIM ID | | 600978 |
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