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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAN2B1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4125 Official gene symbol MAN2B1 Full name mannosidase, alpha, class 2B, member 1 Aliases ,LAMAN,MANB, Gene summary This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq] Location Chromosome: 19   Locus: 19cen-q13.1 Gene position 12777591 - 12757322  Map Viewer Gene orientation minus Gene size 20270 bp Gene sequence >MAN2B1:complement(4020124..4040393):Length=20270 CCCGGCCGGGTCTGGGGGCGGGGCGTTTGCCCGGCCTTTCCAGGGCCGGGGAACCCCAGG AGGAAGCTGCTGAGCCATGGGCGCCTACGCGCGGGCTTCGGGGGTCTGCGCTCGCGGCTG CCTGGACTCAGCAGGCCCCTGGACCATGTCCCGCGCCCTGCGGCCACCGCTCCCGCCTCT CTGCTTTTTCCTTTTGTTGCTGGCGGCTGCCGGTGCTCGGGCCGGGGGATACGAGGTGAG TGGGGCCTCCGAGCTGAAACGTACAGGAGGCAGAGTGAAACCCAGAATACAGTCTAGAGG TGTGGGTGGGTCTGTCCTGTGGGTGTCTAGTGAATGGCTGATGATATGACAGTGTGGTCT GAGTGCGTGCTTTGTGTCATTGCGAGGTCTGGCTGTGCGCATCTGAGTATAGGACTGTGT CTGATTGTACCTGCCTCCGTGTCTCCGGGATGCTTGCCTAGACTTTGTCTGCACTTAACT GTGGGATTGGAGGGGCAGGAGGTGGCAGGGGGTGAGCAGTGTATGTGTGGGGGGAGGTGC TGGCTGAGAGCTGGGACTCTGGAGTCTGCCTGAAATTCCAGCCTAGCTCTTACACTTCCT GAGTGTGTGACGTTGGGCAAGTCACCTATCCTCTCTAAGCCTCAGTGCCTTCATCTGGAA ACTGGGGATAACATCACCCCACCTCCCACGGTGGCCGTCTGCTGTCGGCAAATGCTGAAC AAACATCAGCTACTTCTATTATTATTTTCCCGGAGTGTGAATGAGAGCTGCCCTGTGGGG TTGTGCAAAGTGGAGTTGTATCTATGAGCACAACTATGTATGTGTGTGTCCTGCCTGGGA GGGCCTGGCCTCCTCTGCACATAGGCGAGATCAGGCCTCTCTGAGTCACTCACCTCTAGA TCAAGACTTACTCTGCAGCCCCCGACCTCGGGGGTTATTGACAAGGTATGTGTGTTTGGG GTCCCTGTGCAGACATGCCCCACAGTGCAGCCGAACATGCTGAACGTGCACCTGCTGCCT CACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACCAGTACTTTTATGGAAGTGAG TAGAGGATGGGGACTGGTCCCTGGGATCCCCATGGTCCCTGTAATCCCTCTGGGTCCTGG ACATTAGGGTGGGGCCAGTGCTACCCTAATATCCAGGGTTTGGGCTCCTCTGTCTAGGAA TAACCCCCTTGGCTCTGCTGTTCCCTGAGAGCCTTATCCCTGTTATCCACAGTCAAGAAT GACATCCAGCACGCCGGTGTGCAGTACATCCTGGACTCGGTCATCTCTGCCTTGCTGGCA GATCCCACCCGTCGCTTCATTTACGTGGAGATTGCCTTCTTCTCCCGTTGGTGGCACCAG CAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTGTGCGCCAGGGTGAGCCTACCCCA AGGAAGTGAAAAGAGGAAGCCCAGCCCAGCTTCTGCTTCTGCATCTCTGGTTTCTGAGAT TTGTCATGCCACGTGCAAGCTGTATAACATGCGTGTCGCTCCGCCTGCCTGGACTCTCCA TTTGGAGACCTCCTATACATCCCACAAAGCCCCACCTGCTGTGCATCCTCTGGGAAGCCT GCCATGCAGGGGGCCTCTTTCCCATATCTGGGAACTATGGCCTGGGAGCGACCCCTCTTG TCCTTCCGCCAGAAATGTGTACACAGGCAGGCTTTCACATTCCCAGTATCACCCACCCTA CTCCCACTCCTGGCTCTGACCGCTGACCCTGACCTTGCCTGTCCTGGCACAGGGCGCCTG GAGTTCGCCAATGGTGGCTGGGTGATGAACGATGAGGCAGCCACCCACTACGGTGCCATC GTGGACCAGATGACACTTGGGCTGCGCTTTCTGGAGGACACATTTGGCAATGATGGGCGA CCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGGAGCAGGCCTCGCTGTTT GCGCAGGTGCGACCCGGGACCTCTCTTGGGCCCACTTCTTCACTCACTCTGGCTCCTCCC TCGCCCAGTCAAACCCCGCCCTCTCCCTGCAATCTCACAAGGACCAGGCCCAGGCCTAGG CCTGTTGAAGCCCTGCCCCTTGAGTGAGCCGTAAAGCCAGTGGCTTTTGAGCTCTGGCCT CAGCCGGCTATGCCCAGCCCAGGCTGACCCAGCTCCGGCTGGCTCCGCCCTCTCCCCTAA TAGGCCCCTCTTGGTGTTCTGGCCCCACCCACTAGCTCGGGTCCTGGCTCCTCCCTAAAC CGGGTGGCAAGTGGATGCCTAGGCTGCCTTAAAAACAGGTTCATTACCTGTGCTCAGACC CCATCCATCCTCAGGCTGTGGAAGGGGGAACCTCATTCCTGGAGTCAGGCCTGCTCTGCG CTTTGACAGTGCTGGGGAGGTGAACCTGGGTTCTGATGTTGGACCCGCCCTCTCCCTGCT AGCCCAAGGTGGTGAGTTCTGAAACTTCCCCAAGCTTGGAAATAAGCTGGAGGCCTCTCT GTTTCAGCCCTACGTGTTTTTGTTTTTGTTTTTTGAGACAGGGTCTTGCTGTCATCCAGG CTGGAGTGCAGTGGTGCAATCCTAACTCACTATAGCCTCAATCTCCCGGATTCAAGCGAT TCTCCTGTCTCAGCCCCCCTAGTAGATGAGACTACAAGAGCGCACCACTACGCCTGGCTA ATTTTTAAATTTTTTGTAGACAGTCTGCCCGTGTTGTGCAGGCTGGTCTCAAAAACTCCT GGGTTTAAGTGATCCTCCTGTTTTGGCCTCCCAGAAGGCTGGGATCATAGGCAAGAGCCA CCACATCGACCTAGCACTGCTTTTTAACCTGTGCTCTGACCTGCCCCTCCCAAGCAGAGG GGAGTTTGGTGGTGAGAGGGCTGGGCACTAATTCACACTGCCTTTTCCTCCCTCATCCCC AGATGGGCTTCGACGGCTTCTTCTTTGGGCGCCTTGATTATCAAGATAAGTGGGTACGGA TGCAGAAGCTGGAGATGGAGCAGGTGTGGCGGGCCAGCACCAGCCTGAAGCCCCCGACCG CGGACCTCTTCACTGGTAGGGGGCTTGGTGAGGGCAGGGCCAGCCATGGTGCCACACACT CAGAAGGGCCCTGGGCTTGATATCTGCTCTGTTGTCACTGTCCTGGAATTCCTATAGTCT GGGAACAAAGGCCCTGCATTTCCTTTTGCATTGGGACACAAATTCTGAAGCCCATCCTGG GTGGGACATGGCCGGCTTTGAAACCAGGGAAGGTCTGGGTGATGGGCCACCCCTTGAACT TGGTGTGACCTGCAGGTGTGCTTCCCAATGGTTACAACCCGCCAAGGAATCTGTGCTGGG ATGTGCTGTGTGTCGATCAGCCGCTGGTGGAGGACCCTCGCAGCCCCGAGTACAACGCCA AGGAGCTGGTCGATTACTTCCTAAATGTGGCCACTGCCCAGGTAACCCTGGTGTCCAGAA CCTTCGAGTCCGGTATATACAATACAATGAGCTCTTTCCATGGTACAGGCATCCCCTAAC ACGTTCTCCTTATTTTTAATTTTTTTGAGACAGTCTTACTCTGTCACCCAGGCTGGAGTG CAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAACAAGCACATCCA GCTAATTTTTGTATTTTTGCACTGGGGTCTCATCATGTTGTCCAGGCTGGTCTCAAACTC CTGAGCTCAAGTGATCTGCTTGCCTCGGCCTCCCAAAGTGCCGGGATTACAGGCATGAGC CACCGCACCTGGCCTCTATTTTTAACATTTTTATTTATTTATTATTATTTTTTTTTTTTT GAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTG CAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGAAGCTGGGAT TAGAGGCACCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGACAGGGTTTCGTC ATGTTGACCAGGCTGGTCTTGACCTCAGGTGATCTGCCCGCCTCAACCTCCCAAAGTGCT GGGATTACAGGTGTGGGCCACTGTGCCTAGTCTATTTTTAACATTTTTATTGAGAATTCC TTTTTTATTTTTTTTAGACTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCG GCTCACTGCAACCTCCACCTACTGGGTCCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTA GCTGGGATTACAGGTGCCCACCACCATGCTCGGCTAAGTTTTATGTCTTTTTAGTAGAAA GGGGGTTTCACCATATTGGCCAGGCTGGTCTCGAACTCCTAACCTTTTGACCCACAGCCT TGGCCTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGTCCAGCCTTTAACATTTT TATAATTAAAAAACATTATTTTTTCACAGAGATAAGGTCTCACCATGTGGCCCAGGCTGG TCTCAAACTCCTGAACTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTAGGATATA GGTGTGAGCCACCATGCCTGGCATAACACGTTCTCCTTAAAAAAATTTTTTTTTCCTTTC TTTAAAAATTGATGGCTGGGCATGGTGGCTCACGCCTATAATCCCAGCATTTTGAGAGGC CGAGATGGGCAGATCATCTGAAGTCAGGAGTTCAAGACCAGCATAGCCAAAATGACGAAA CCCTGTCTCTACTAAAAATACAAAAATTAGTCGGGTGTGGTGGCGCACGCCTGTAATCCC AGCTACTTGGGAGGCTAAGGCAAGAGAGTCGCTTGAACCTGGCAGGTGGAGGTTGCAGTG AGCCGAGATCACGTCACTTCACTCTAGCTTGGGCAGCAGAGTGAAACTCTGTCTCAAAAA AAAAATTGTTTTAGATTAATTTTTTTTTTTTTTCTTGAGACAGGGTCTTGCTGTGTGGCC CAGGTTGGTCTTAAACTCCTAGACTCAAGCGATCCTCCTGCCTCAGTCTCCTGAGTAGCT GGGATTACAGGTGTGAGCCCCTGTAATCATGTTCTCATGCCCCCTGGAGGAAGATGCTAT TCTATTCACCATCACAATGTCCCCCTCCTGGATTTATGTGCATTCCTCATTAGAAGAGAT AGCATAGGCTGGGCAAGAGATAGCATGGCATGGTGACTGGATGCCCTCTTCTAGGTAGTG GGTCCAAGAGAACTGCTCAACAACTGGTGGCTACTTTTATCTGTGTCCCCACGCTCCCAA GTGCCATACCCCCACCCATGCCTGTGCACCCAACATCCTTGACCCCATATACATCAAAAC ACAGCTATACACAGGGATGGCCCAGGATCCTCTGGCTTCAGGACTCCCCTCTTGCCTGCA GGGCCGGTATTACCGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATGA GAATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGGCTGGTAAATGCGCAGGT CAGTGCGCCTACCCTGTGGTACCCTTGTGCACATGTGCGCTTGCATCCGGGGGCCTTGGG TTATGTGCATAGCTCTCAGTGCTGTCTTTGTTTTCTATTGTTCTATTGTGGTCATTCTAT AACAAATGACCACACACTTAGCAGCTCAAAACAACAGAAATACATTGTCTTACAGTTCTG TAGGTAAGAAGTCCAGCATGAGGCCGGGCGCAATGGCTCATGCCTGTAATCCCAGCATGT TGGGAGGCTGAGCCGGGCAGATCACGAGGTCAGGAATTCGAGACCAGCCTGACCAACATG GTGAAACGCTGTCTCTACTAAAAATACAGAAATTAGCTGGGTGTGATGGTGCGTGCCTGT AATCCCAGCTACTCGGGAGCCTGAGGCAGGGGAATCTCTTGAATCCGGGAGGCGGAGGTT GCAGTGAGCGGAGATTGTACCACTGCACTCCAGCCTGGGCCACAGAGAAAGACTCTGTCT CAAAAAAAAAAAAAAAAAAAAAAAATCCAGCCTGAGTCTCACCAGGCTATAATCAAGGTG TTGGCAAGGCTGTGTTCCTTCTGCAGTCTCTAGGAGAGAATATAATTTCCTTGCTTTTTC CAACATCTAGAAGTTACCCACATTCAAAATCTATTCTTGGCTCCATCTTCAAAGCCAGCC ACATAGCATCTTTCTGACCCTGTTTCTGTAATCACATCCCTTTCTCTCATTCTCACCTCT TCTGCCTCTCTCTTCCACATTTTATTTATTTACTTAGAGACGGAGTCTCGCTCTGTCGCC CAGGCTGGAGTGCAGTGGCGTGCTCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAG TGATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGACTACAGTCGCGTGCCACCACGCCCA GCTAATTTTTGTATTTTTAGTAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCGATT TCTTGACCTCGTGATCCACCCCGCTCGGCCTCCCAAGGTGCTGGGATTACAGATGTGAGC CACTGTGTGGCCTAATTTCCCTACTTTAAGTTTGGCTGATGAACAACCTCAATTCCATCT GCAACCTTAATTCCCCTTTTGCCATGTAATCTAATGTGGTAATAGGTTCTGGGGATCAGG ACATGGACACTTTTGGGCAGTTATCATTTTACCCAACACAGATGTGTTAGTGTTTTGCAC TAAGTGGCCTGTGGCTGTGGCTGTGTGCACAGTCAGTCACTCTCATCAGCACAGAAACTT GTCTCCCCTCTCCCATCTCAGACACCCCTTCCCATCAATCTTGTCCTCACTACGGTGCAA TCTCCATTCCCACCTTCCACTCGCTCCCAGCACTGCTATTTCACCAAAACAGCTCTTTTA TGTCATTTATTTTTATTTATTTTTTCTTTTTAAAATTTTATTTATTTATTTATTTATTGA GACAAGAGTCTTGCTTTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTTGCCTCATGGC AACCTCTGCCTCCTGGGTTCTAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACT ACAGGCATGTGCCACCAACCCTGGCTAATTTTTGTATTTTTAGTAGAGGCAGGGTTTCAC TATGTTGGCCAGGCTGGTCTCAAAACTCCTGACCTCAGGTGATCCGTCCGCCTTGGCCTC CCAAAGTGTTGGGATTGTAATCTGAGGTGGGCGGATCACTTGAAGACAGGAGTTGGAGAC CAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACTACAAATTAGGTGGGCG TGATGGCACTCATCTGTAAGACCAGCTACTCGGCAGGCTGAGGCAGGAGAATCGCTGGAA CCTGGGAGGCGGAGTTTGCAGCCAGCTGAGATCGTGCCACTGCACTCCAGCTTGGGCGAC AGAGTCAGACTCAGTCTCAAAAAAAAAAAAAAAAAAAAAAGTTTATTGAGCACCTACTGT GTACATTGGGGGACACAGCTCGTGCAAAACAAACATCCTTTTCCTCACATAGGTCACTTT CTTGTTCCTCCACCTTGCTCAGGTGAAAGTGCACCTCCATTCATTATAAAAATTGTGTCT AGGCCGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGG ATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACTCCGTCTCTACTA AAAAATGCAAAAAATTAGCCGGGTGTGGTGGCGGGCACCTGTAGTCCCAGGTACTCATGA GGCTGAGGCTGGAGAATGGCGTGAACCCAAGAGGTGGAGCTTGCAGTGAGCTGAGATTGA GCCACTGCACTACAGCCTGGGCAACAAAGTAAGACTCCGTCCCAAAAAAAAAAAGTTGTG TTTTTTGGTAACAATCTGACAGTCCTGCAAAACGATTATTCCTGCCCTATAATGTCACAC TTAGTTTTTCCACAAAAGTTTTTAATAATAAAGTTGGAATTATTGTAAAAGTTTAGTAAA ATTTCAGGTTTATTCTTGCATCTCTGAAATCCTTTTAAAAAAGGCTAGTGGTCATGTTTG ACTTCAGCCAAAATTCATTTTCACACCCAACCATTGGCTTGCACGCCAAATATGTATTTA GAGAAACTGAACCTATGGGATGCATGAATGTGCACACATGTGTGGAAGTGTGGGCCCCCA GGAAGGTGCGGACTCCCGAGGGCTCACTCCGTCGCCTCCCCCAGCAGCAGGCAAAAGGAA GCAGTGTCCATGTTCTCTACTCCACCCCCGCTTGTTACCTCTGGGAGCTGAACAAGGCCA ACCTCACCTGGTATTTGGGGAAACTGGGGAGCTTGGGGGGGTTGGCATGCCCCGTGGGTC ATGACCCTGCCCTCAATGCCCCTGCCGCTGTAGGTCAGTGAAACATGACGACTTCTTCCC TTACGCGGATGGCCCCCACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCCCTCAA ACGCTACGAGCGCCTCAGCTACAACTTCCTGCAGGTGGGTAGGAGCCGGGCTAGAGGGGG CATGCAGCCCCGAGGCCCGACAGGCTGGGCGCCCCAACATACCCCTCTGCCTCCAGGTGT GCAACCAGCTGGAGGCGCTGGTGGGCCTGGCGGCCAACGTGGGACCCTATGGCTCCGGAG ACAGTGCACCCCTCAGTAAGTGTCGGGCCCAAGAGGGGAAGAGGTTTGCGGCTGAAGTTG GAAACCACCCCTAGGCCGCCCCCCTCGAGTTTCTTCTTTTTTTTTTTTTTTTTTTTTTTT TTTGAGACGGAGTCTCGATTTGTCTCCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCA CTGCAAGCTCCACCTCCCGTGTTCACGCCATTCTCCTGACTCAGCCTCCCGAGTAGCTGG GACTACAGGCGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGT TTCACCATGTTAGCCAGGATGGTCTCGATCTGACCTCGTGATCCGCCCGCCTCGGTCTCT CAAAGTGCTGGGATTACAGGCGTGAGCCACCGCCCCCAGCCGTCCTCGAGTTCCTTCTTA AAGCCTCTAAGAATCCTGCCCGCCAGCACCGGACCTTTCGCTTCCCCTTGGGGTCTCAGC TGAGTCCCACAGAACCTCACCGGACTCATTGTCTATGAGCAGATGAGGCGATGGCTGTGC TCCAGCATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTGGCCAACGACTACGCGC GCCAGCTTGCGGCAGGCTGGGGGCCTTGCGAGGTGCGCGGGGCGAGACTTGGGAGACACG GGGGTGGAGACAGGAAGGGGCGGGGCCAGGGCCTGGGAAAGGGGACAGAGACAGGTGTGA GGCGTAGCCGAGAGCCCTGTGGCGGGGCTACAAGGGCTCGTGGGGGCGGGGCTTGTAGGA GGCGGGGAAAGATACAGGAACGGGGCGGGGCTTTGGAGGGGGGAAGGAGGCGGGGCGTGG GCAAGAGGAGGCGGAGACAGCTATGGGGTATAGTCAAGGGCAGCAGGGTGGGGCTAGAAG GGGTTTTGGGGCGACTCTTGAGGGAGGCGGGACAGAGACCGGAACGGGGCGGGGCCTGAG GAGAGGGGAGGAGTCAGGCCTGGCGTCCTGAACCCACCGGTCCCTTTGCGCTCTTCCGCA GGTTCTTCTGAGCAACGCGCTGGCGCGGCTCAGAGGCTTCAAAGATCACTTCACCTTTTG CCAACAGCTAAACATCAGCATCTGCCCGCTCAGCCAGACGGCGGCGCGCGTGAGCCGGGA CGGGAGGGGTGGATCTAGGGCAGATGGGCTTTAGAGGGGGTAGTTGGAAAATGTTTTTGG AGGACTATACAGGAGTGAAATTACGTGGGCTGCGAAGCTGGGTCAGCAGAGAGAACAACG CATCTCGAGGGGGCTTGGCCTTAAGTGCCGTGACCACACTAGGACCAGCCAGGGGTGTTT CTGTGCAAAGTGGGTGGGTTTGGAGAAGGCCTGCTGTGACCCATGCCCTCTCTGACCCCC GCCTCCCCAGTTCCAGGTCATCGTTTATAATCCCCTGGGGCGGAAGGTGAATTGGATGGT ACGGCTGCCGGTCAGCGAAGGCGTTTTCGTTGTGAAGGACCCCAATGGCAGGACAGTGCC CAGCGATGTGAGCCCAAACAACGAATATTCCCCCGCTGGGACTCCTCCCCCAGTGGGCAT TTCCTCATCGCCCCCATGGATATCGCCTGCTTCCATGAATACCTCCCACTCATGCATATC TCTTCCCCCCTCTTGTATCTTCTCCCTCTGCCCCTTAATATCAGTCTCCCCTTGGGAACA TATGCCTCCTGTGAGTGGTCCTCCCTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTG TCACCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTTCAAACTCCGCCTGCTGGAT TATAGGCATGAGCCACCGTGCCTGGCTGGTCCTCCATTTTAATACCCCGCTTCCCCAGGA AAATTTATTGCTGTTTATGGACATCTCCTTCATTCCAGAAAACGTCCTCCCCCAAACCTC TTCCTCCCCCGAGAACCTGCCTCAAGGGTTTCTTCCCCTACTTCCTCCTTCACTCCCCCG ACTCCATGGTCTCTCCACCCTCCCGGTGGGTTTTTTTTTCCACCTGGTGAATCTTCTCTG CAATCATTTCCTTGGAATCTGACTGTCCCCCCACCACACACACCTCCATTTCCTTTCCCC ATCTCAGGACTCTTTTCCTTCCTTGAGTTTTTTGTCTCCATGCATGTATAGCTTTCCATG GGTACTCTTGACTCAGTTTCCCTCCTCCTTTATCCGAGGTGGTAATATTTCCCAGCTCAG ACAGCCAGGCGCACCCTCCGGAGCTGCTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCA GCACCTATTCAGTAGCCCAGGTGCCTCGCTGGAAGCCCCAGGCCCGCGCACCACAGCCCA TCCCCAGAAGATCCTGGTCCCCTGCTTTAACCATCGAAAATGAGGTGAGACCCCATTTCA ATCCCCTTTCCTGCTCCTGTGACAAATTTGAAGTGTCATGGTGAGCTGTGTGGACTCTGG GTCAGCAGGTCCCTAGGCTTATGACCTCCTGTCACAACTCCCCTCATTGTGTGTCCTTGA GCAAGTGACCTTTGTCTGAGCCTCAGTGTCCTTTCCTGGGACTGTTATGAGGACCCAGTG TGATCATGGGTGACACTTGACAGACATGTCAGAGTTGGTGGCAGGTGGTGGTTCGCAATT TTGGCAGGGACGTTTCAGGGAAGGTGTTCCCGATAAAGGTGACATTTAAGATATGACCTG AGGGAGGGAGCCGTGTGGCTATTTGAAGGAAGAGAGATCCAGGTGGGGAGAGAATAACAG GCATAAAAGCCTTCGAGCAGGAGAGTGTGCAGAATTCCAGGAGCCACAAGGAGCTCAGTG TGGCTGAAGCAGGGTGAACGGGTGACAGGTCAGACCTTGAGGGCCTTGAGGACCAACAGG AAGACTTTGGCTTTTGCCAGTCATTGTTGCTCATGTGTCTACTCCTAGCTCTTTGGGAGG CTGAAGCGGGAGGATCACTTGAGCCCAGGAGTTGTCCCAGCTAATTGGGAGGCCCAGATG GGAGGTTTGTTTGAGCTGGGGAGTTCGAGGTTGCAGTGAGTAATGATTGTCCCACTGTAC TCCATCCTGGCAACAGAGTGAAACCCTGTCTGAAAAGAATAATAATAAAATAGGCCAGGC ATCGTGGATTATACCTGTAATTCTAGCACCACGGGAGGCTGAGGTGGGTGGATCTACTGA GCTCAGGAGTTTGAGACCAGCTTGGGCAACATGGTGAAACCCAGTCTCTACAAAAAATTA GCTGGGGGTGGTGGTACACGTCTGTAATCCCAGCTACTTGGGGGCTGAGGAAGGAGGATT GCTTGAGCCCAGGTGGCAGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCT GGGTGACAAAGTGAGACCCTGTCTCAATAAAATAAAATAAAAGAAGTTCTGCAGTAGGAC TGTTCATGTTAGGAAGAAAACATCTTTTTCATATTTTTATTAAAATAAAATAAAAGAAGT TAAAACGTTCCCACAGGCCCCTAAAAGTCTTGTGAGTTCTGGCATTGTGGTTCACACATC AGATGCCCAAGTTGGCCCTGGTCCGCAGCAGAGGAGGGCTTTGATGGGACTTAGGGTATC ACAGGTGTGCTCTGGCTGTTGTGGGGAACAGACTGTAGGCAGCCAGTGTGGAAGTGCAGG GACCTGGAAGGGGTTGACTGCACTGGCCCTGGAAGGCCCTGGTAAGAGGTGGTGAGGTTG AAAATAAGGTTGGGGGGGCCGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGA GGCCGAGGCAGGCAGATCACGAGGTCAGGAGATGGAGACCATCCTGGCTAACACGGTGAA ACCCTGACTCTACAAAAATACAAAAAATTTAGCCAGGCGTGGTGGCGAGCATCTGTAGTC CCAGTTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGAAGGCGGAGCTTGCAG TGACCTGAGATGGCGCCACTGCATTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAA AAAAAAAAAAAGAAAAAAAAAGAAAAAAAGAAAAGGCTGGGGTGGGCACGTTGGCTCATG CCTGTAATCCCAGGACTTTGGGAGGCTGAGGCTGGCAGGTCACCTGAGGTCAGGAGTTTG AGACCAGCCTGGCCAACACAGTGAAACCTCGTCTGTACCAAAAATACAAAAATTAACTGG GCGTGGTGGTACACACTTGTAGTCCTAGCTACTCGGGAGGGAGAGGCAGGAGAATCACTT GAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGG GACAGAGCAAGACTCTGTCTCAAAAGCAAACAAAAAAAAAATCAGGTTGAATGGCTGGGT GTGGTGGACTGCTTGAGCCCAGGAGTTGGACACTAGCCCCAGGCAACATAGTGGGACCCC CATCTCTAGAAAACAAATTTAAATTTTTTTTTTTTTAATTTAGTAGAGATGGAGTTTCAC TATGTTGGCCAGGCTGGTATCAAACTCCTCACCTCAGGTTATCCACCCAACTTGGTCTCC CAAAGTTCTGGGATTACAGGTGTGAGCCACCACGCTCGGCCCTAAAAAAATTTTAAATTG AGAAAAAAAGGGGCCAGGCGTGTTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTG AGGGGGGGGTGGATCATGAGGTCAGGAGTTCGAGACCAGCATGGCCAATATTGTGAAACC CTGTCTCTAATAAAAATACAAAAATTAGCCAGGTGTGGTGGCATGTGCCTGTAGTCCCAG CTATTCAGGAGGCTGAGTCAGGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAG CCAAGATCACGCCACTTTCTGCACTCCAGCCTGGGCGATAGAGCGAGACTCAGTCTCAAA AAAAAAAAAAAAACAAAAAACCCAGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCC CTTTGGGAGGCCAAGGCGGGTGGATTACCTGAGGTCAGGAGTTGGAGACCAGCCTGACCA ACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCATGTG CCTGTAATCCCAGCTACCCAGGAGGCTGAGGCAGGAGAATTGCTGGAACCCAGGGGCAGA GGCTGTAGTGAGCAGAGATTGCGCCCCTGCACTCCAGCCTGGGCGACACAGCAAGTTTCT GTCTCAAAAAAAAAAAATAAAAATCCGGCTGGGCACAGTGGCTTATGTCTGTAATCCTAG TACTTTGGGAGGCCAAGGTGAGCAGATCACTTGAGTTCAGGGGTTTGAGACCAGCCTGGC CAACATGGTGAAACCCTGTCTCTACTAAAAATATGAAAATTAGCCAGGCGGGGTGGTGGG CACCTGTAATCCCAGCTACTTGGATAGCTGAGGCACGAGAATCACTTGAACCCGGGAGGT GGGGGGTGCAGTGAGCCAAGATTGCACCACTGTACTCTAGCCTGGGCTACAGAGTGAGAC TCAGTCTCAAAAAAAAAAAAAGAAAAAAGAAAAATTAAAAAAAGAAAACACACACACATA CACACACAAACCCATCTGTGGACCCTTTTCTGCCCAGCACATCCGGGCAACGTTTGATCC TGACACAGGGCTGTTGATGGAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTTCG CCAGACCTTCTTCTGGTAAGGGAAGATCACCAGGCCTGAGGGTGGGGTGGTGGTGCTCGG CATGGAGCTAGGGCCCCTTACCTGACTCTCACCTGCCCCAACTCCAGGTACAACGCCAGT ATAGGTGACAACGAAAGTGACCAGGCCTCAGGTGCCTACATCTTCAGACCCAACCAACAG AAACCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGGTCAGGGACTAGGAA TGATGAGTGGGCAGTTGGGAATGGGGAAGTTATGGAGCCCAAGAGGGTGGTGGGCCATGT GTAGAGTGAGGGTAGGGGAGGATTTACTTTTCCTTCAGATCAGTGGGCTAAGACCCACAG ATCAGCGGGGGAAATATTTGAGGGTCCTTCCATAGAATTGATATTCATAGCTGGTCGTAT GAGAGTCTCCCCATAGGACACATCATACAAAGCCATTCACATCTGCTGTGGACGTTTACA TACTTAGTTTTGGAAATTGGGGGTGGGGCATTCCCACTTGGCCCATGAATCAGGAGAGCC AAATATCACTGCTTGAAGAATTCACCAAAGTCTGTAGTAAGAGGAGCTTCTATCTGGAGT GAATATTTGAGAGTCCACCCTTGGATTGATTGGGTTTGGGTGAGTCTCAGGGTGAATGCC TATGGGTGCATCTGGCTAGGAACAGTGGTTTCCCAGGGCCTCTCATTGATGTTTGACTTT CATAGATGACAAAACTCACATTTGTCCACATTCAAGAGCCTCGCGTTTCATGTGAGTCCC TTTGAGATGAATGTCTGCATATCTGTATATAGTTTTGCCTGTTCTAACAGAGTTACCCAA ATTAACTGTGACTAGAATAAGATAGAAGATTATTTTCTTCTAACAAAAAGTCTGGCTGTT AGTCCAGAGAAAGTGGGGTGGTTCCATAATCACCCAGGACCTCCTCTTCTATCTTGTTGC TCTGCCTTCCCCAATATTCAGTTTCCACCTCATGGTCCAAGATAGCTGCTGAAGCTCCAG CCGCCACATTTGTGTTTGAGTCAGTAGCAGAGGGACAGGGGCAAGGAACATTGTTGACAC CACTTGGATCACTTTCTATGGGGCAAACTGGTCACTCAGCTACTGATAGCCTCAGGGAAG ACTGGACAATATAGTCTTTATCCCAGGTAGCCATGTGCCAAGCTAGAATCCTATTCTATG GGGCAATGGTGAACAGGAGGCGTTTATGCCACGCTCAAGAGTGATGTGGTAAGCCAGATG CAGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGACTGAAGCAGGAGGATCGCTGAGC ATAGGAGTTCAAGACCAGGTGGGAGCATTTGCTGATTAGGTGCCTACATAGTGATGCCCT GTCTCAAAAAAAAAAAAAAAAAAAGAGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAG CACTTTGCGAGGCAGAGGCAGGCAGATCATCTGAGGTCAGGAGTTCAAGACAAGTCTGGC CAACATGGATAGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGGGTGGTGGCA GGTACCTGCAATCCCTCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGG CGGAGGTTGCAGTGAGGCAAGATTGTGCCACTGCACTCCATCCTGGGCAACAAGAGCAAA ACTCTGTCTCAAAAAAAAAAAAAGAAAAAAGAATTATGTGGGCCAGGCGCGGTGGCTCAC GCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCTGATCACGAGGTCAGGAGATCGA GACCATCCTTGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCGG GTGTGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGT GAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCCGCCTGGGC AAAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAGAATTATGTGGCGGTGACTG AAGGTTGACCTTGATGTAGGCCTTAATGGGGTTTATGGCCAGGGTTGGGGGACATTTGTA GGACTCACCTCTGCTCAGGTACAGACTGACATCCACCTCACCCGTGTGCCCGCAGACACC CTTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGTTCCCAGGTGGTTCGCCTGTA CCCAGGACAGCGGCACCTGGAGCTAGAGTGGTCGGTGGGGCCGATACCTGTGGGGTGAGT GGCACAGGCTGGGAGAGGGGTGTGGAAGCAAGGGCAGAGGGGTTTATCCAAGGCTCACAA CCTTGCCATCCCATTGGGTACAGCGACACCTGGGGGAAGGAGGTCATCAGCCGTTTTGAC ACACCGCTGGAGACAAAGGGACGCTTCTACACAGACAGCAATGGCCGGGAGATCCTGGAG AGGAGGTGGGGGGTGACTGAGAGCACTGAGGGGGTGGTCTGTGGTGTGTTGGGGCCCAGG GGTGGTGAGGGAAATTTGCTGATTACATGAGTGTGGGAGACAGAGGACGAAGGGAGAGTG AAGGGCGGGGGAGCCAGGCAGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA AGCCGAGGCGGGCAGATCACAAGGTCAGGAGATCGAGACTATCCTGGCTAACATGGTGAA ACCCCGTCTCTACTAAAAATACAAAAAAATCAGCCGGGTGTGGTGGCGGGCACCTGTAGT CCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAAGCCGGGAGGCGGAGCTTGCA GTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCAA AAAAAAAAAAAAAAAAAAAAGAGTTGGGGAGCCAGATCCCAAGCCTGATCAGCTCACCCC CAACCCCAGGCGGGATTATCGACCCACCTGGAAACTGAACCAGACGGAGCCCGTGGCAGG AAACTACTATCCAGTCAACACCCGGATTTACATCACGGTAGCTCTCCCCCATCCTGCACC TCCCCACCTCGATAGAAAGGGAATCACCCCTTATCTGCAGCATCTCAAAGCTGCCTGGGG TTGGGGTTGACTGCCCTCTACTTTCACCCTTCAACTCCCAGGATGGAAACATGCAGCTGA CTGTGCTGACTGACCGCTCCCAGGGGGGCAGCAGCCTGAGAGATGGCTCGCTGGAGCTCA TGGTGAGTGGGTCAGAGCCCCATCCGAGCCAGGGTCCTCCCAACCTGGACCCCTGCTGGA CCTTGAAGGCTGTTTCTGGCCCAGTTCTCTGCTTTCAGGCCCCACTAAGCTGAGGACTCC GTTTCTTTCTTTTCTTCTCTTTGAGACGGAGTTTTGCTCTTGTTGTCCAAGCTGGAGTGC AATAGTACTATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTGTCCTGCC TCAGCCTTCCGAGTAGCTGGGCTTACAGGCACACACCATCACGCCCGGCTAATTTTGGTA TTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTTACCTCA GGTGATCCACTCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAACCACCGCTCC CGGCCAAGGACTCCATTTCTGTGTGTGGCTTTTCCTCTCCGTTTTTCTCCATCTCCTGCC CAGGCTCCCTCCACGCTCTGGCGTGCCATATCCAGGCCCCCCTGTTAGGCATTTACCTCC TTCCGGCCTGGTTCCCATGCCTACTTGGATCCTGCCTCTGCTGGGGTTGCCCTACCAGAC CCTCACCTTCATCCTCATCCGTTCCTCCCACCCTTTAATTTCTTTTGACATTCCCACACG CCCTTACCCAGTTTCTGGCCCAAGGACACCCACAAACCCACGACTCTCACCCCCTCCTGG CCACTCTCCCCCCAGGTGCACCGAAGGCTGCTGAAGGACGATGGACGCGGAGTATCGGAG CCACTAATGGAGAACGGGTCGGGGGCGTGGGTGCGAGGGCGCCACCTGGTGCTGCTGGAC ACAGCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGGAGGTCCTGGCCCCT CAGGTGGTGCTGGCCCCGGGTGGCGGCGCCGCCTACAATCTCGGGGCTCCTCCGCGCACG CAGGTGAGGGGCAGCGGGGTAGGCAGAGAGGACCGGATTGAAGTCTACCAGGGAGCCGGG TTTGGGTGCGGAGTTTCCTAGGCTCAGCGGGGATCCATTTGGCCATAATTAGCCCCAAAC CCTCGGGCCAACCCCATCCCCTGGGCAGTCCCCGCCCAGTGCCAGCCCAGTCCCAACCCC CCTGGACTGTGTAGAGGCACAGCCCTAGCTCATGCCCCTAAACCACCAACTCACCTCCGG CCCCGCCCATTTCACTTTAGCCCCGCCCTCTCACCGCCCCCAGGCTCTGTCCTGCCTCAC CCAGCCCCGCGGCTTCAGCCCCGCCGTAACTCCCAAAGTCTCAGGTCACATCAGTTCTGC TCCATCGGGACTCGAACCCTAAGCTTGGGACCGACCCATCTCCCCATTGGCTCAGTCCTC CCTGTCACGGCCCTGGCCGCTCCTCTCGGCTGAGCCTTGCCCCTCTCCGGCGAAACCCCG CCCCTACAACCTAGCCCTGCCTCCTGACCTGGCTCGGCCCCGCCCTTCTCCATCCAGGCC CCGCCCCTCTCCAACTCAGCCCCGCCCTCTCTCCCGCAGTTCTCAGGGCTGCGCAGGGAC CTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTG CGCTTGGAGCACCAGTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTT ACCTTGAACTTGAGGGTGAGAAGGGCAAAATTGAGAAGGAGATCGGAGAGAGGCAAGAGA GAGGGAGAGAAGAGAAACCTGGCTTTGCCCCAACTCATCTGGGCCCATCCCCTTCCCCGC AGGACCTGTTCTCCACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACC AGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGTGGGGCCCTGGTCA GGGGTAGGGAAGGGGTGGAGTCTTACCTGGGGCCGGCAGGTGGGGGCAATGTGTGAGGCA TGGGATGTTGGCCAGGACCCAAAAAGGTCATGAGGGTATGGGGCAGAGTCCAGACCCAGG TTAGGGGCTTAAAGGATCTGAAATGGGTGCGGCAAACCAGGAATGGGTCTTGAGGTTTGT GGGTGCTGTTTAGTCCCAAGAACAAGATTTGAAAATCCCCATCCATGTCTAGTTCTGGGA GGGTGTTCATCACCCCTGGGGTCAGATTGAGGGTACGAGGACAGTGGCCAGATTGAGGGT ATGAGGACATTGGACCTGGGGGTGGTATTCGGGGCCGGGGAAGCAGGTTAAGAGTCTGGG ATTGAGGCCCTGGAGACAGATTCGGGGATATGCAGCTGTGTCTAGACCCAGGGGAGGAAG CATCGTGGGGTGAGTCAGAGGAAGTCTGCACCTCCTCACTCCTCCTTCCCCCTGCACCTC TCCAGGCCCCACACCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGA ACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGATGGTTAGGT CTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGAC TCTCCTCTTGGGGCTGCTGCCATTAAAACGCTACTACTAAGACTCAGGTC OMIM ID 609458