Entrez gene ID | | 4143 |
Official gene symbol | | MAT1A |
Full name | | methionine adenosyltransferase I, alpha |
Aliases | | ,MAT,MATA1,SAMS,SAMS1, |
Gene summary | | This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q22 |
Gene position | | 82049434 - 82031576 Map Viewer |
Gene orientation | | minus |
Gene size | | 17859 bp |
Gene sequence |
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OMIM ID | | 610550 |
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