Entrez gene ID | | 4145 |
Official gene symbol | | MATK |
Full name | | megakaryocyte-associated tyrosine kinase |
Aliases | | ,CHK,CTK,DKFZp434N1212,HHYLTK,HYL,HYLTK,Lsk,MGC1708,MGC2101, |
Gene summary | | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13.3 |
Gene position | | 3801810 - 3777967 Map Viewer |
Gene orientation | | minus |
Gene size | | 23844 bp |
Gene sequence |
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OMIM ID | | 600038 |
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