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Gene information for CD46 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4179
Official gene symbolCD46
Full nameCD46 molecule, complement regulatory protein
Aliases,AHUS2,MCP,MGC26544,MIC10,TLX,TRA2.10,
Gene summaryThe protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q32
Gene position207925383 - 207968861  Map Viewer
Gene orientationplus
Gene size43479 bp
Gene sequence
OMIM ID120920