Entrez gene ID | | 4194 |
Official gene symbol | | MDM4 |
Full name | | Mdm4 p53 binding protein homolog (mouse) |
Aliases | | ,DKFZp781B1423,HDMX,MDMX,MGC132766,MRP1, |
Gene summary | | The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q32 |
Gene position | | 204485511 - 204527248 Map Viewer |
Gene orientation | | plus |
Gene size | | 41738 bp |
Gene sequence |
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OMIM ID | | 602704 |
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